| pubmed-article:15950724 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15950724 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:15950724 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15950724 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:15950724 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:15950724 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:15950724 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:15950724 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:15950724 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:15950724 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:15950724 | lifeskim:mentions | umls-concept:C1283195 | lld:lifeskim |
| pubmed-article:15950724 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:15950724 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15950724 | pubmed:dateCreated | 2005-6-13 | lld:pubmed |
| pubmed-article:15950724 | pubmed:abstractText | The lambda5 and VpreB genes encode the components of the surrogate light-chain which forms part of the pre-B cell receptor and plays a key role in B cell development. In the mouse, the lambda5 and VpreB1 genes are closely linked and are co-regulated by a multi-component locus control region. To identify the sequences that regulate lambda5 and VpreB1 expression during B cell development, we have comprehensively mapped the DNaseI hypersensitive sites (HS) in the lambda5-VpreB1 functional domain. The active domain contains 12 HS that are distributed at high density across the 18.3 kb region that forms the lambda5 and VpreB1 functional unit. Analysis of a reporter gene driven by the VpreB1 promoter in transgenic mice identified a novel enhancer associated with two HS located upstream of lambda5. The lambda5-VpreB1 locus was also found to be closely linked to the ubiquitously expressed Topoisomerase-3beta (Topo3beta) gene. The VpreB1 and Topo3beta genes have entirely different expression patterns despite the fact that the two promoters are separated by a distance of only 1.5 kb. | lld:pubmed |
| pubmed-article:15950724 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15950724 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15950724 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15950724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15950724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15950724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15950724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15950724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15950724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15950724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15950724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15950724 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15950724 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15950724 | pubmed:issn | 0161-5890 | lld:pubmed |
| pubmed-article:15950724 | pubmed:author | pubmed-author:DillonNiallN | lld:pubmed |
| pubmed-article:15950724 | pubmed:author | pubmed-author:GeorgiouAndre... | lld:pubmed |
| pubmed-article:15950724 | pubmed:author | pubmed-author:WebsterZoeZ | lld:pubmed |
| pubmed-article:15950724 | pubmed:author | pubmed-author:ChowCheok-Man... | lld:pubmed |
| pubmed-article:15950724 | pubmed:author | pubmed-author:SabbattiniPie... | lld:pubmed |
| pubmed-article:15950724 | pubmed:author | pubmed-author:MinaeeSophiaS | lld:pubmed |
| pubmed-article:15950724 | pubmed:author | pubmed-author:FarmerDeborah... | lld:pubmed |
| pubmed-article:15950724 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15950724 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:15950724 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15950724 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15950724 | pubmed:pagination | 1283-92 | lld:pubmed |
| pubmed-article:15950724 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15950724 | pubmed:meshHeading | pubmed-meshheading:15950724... | lld:pubmed |
| pubmed-article:15950724 | pubmed:meshHeading | pubmed-meshheading:15950724... | lld:pubmed |
| pubmed-article:15950724 | pubmed:meshHeading | pubmed-meshheading:15950724... | lld:pubmed |
| pubmed-article:15950724 | pubmed:meshHeading | pubmed-meshheading:15950724... | lld:pubmed |
| pubmed-article:15950724 | pubmed:meshHeading | pubmed-meshheading:15950724... | lld:pubmed |
| pubmed-article:15950724 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15950724 | pubmed:articleTitle | Mapping and functional analysis of regulatory sequences in the mouse lambda5-VpreB1 domain. | lld:pubmed |
| pubmed-article:15950724 | pubmed:affiliation | Gene regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 ONN, UK. | lld:pubmed |
| pubmed-article:15950724 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15950724 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16136 | entrezgene:pubmed | pubmed-article:15950724 | lld:entrezgene |
| entrez-gene:22362 | entrezgene:pubmed | pubmed-article:15950724 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15950724 | lld:entrezgene |
