15950464

Source:http://linkedlifedata.com/resource/pubmed/id/15950464

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001128, umls-concept:C0086440, umls-concept:C0166415, umls-concept:C0243192, umls-concept:C1880355
pubmed:issue	14
pubmed:dateCreated	2005-6-24
pubmed:abstractText	A SAR study was conducted on chromane-2-carboxylic acid toward selective PPARalpha agonisim. As a result, highly potent, and selective PPARalpha agonists were discovered. The optimized compound 43 exhibited robust lowering of total cholesterol levels in hamster and dog animal models.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Carboxylic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Chromans, http://linkedlifedata.com/resource/pubmed/chemical/Hypolipidemic Agents, http://linkedlifedata.com/resource/pubmed/chemical/PPAR alpha
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	0960-894X
pubmed:author	pubmed-author:AgrawalArun KAK, pubmed-author:BergerJoel PJP, pubmed-author:BoueresJulia KJK, pubmed-author:IppolitoMarc CMC, pubmed-author:KoyamaHirooH, pubmed-author:MacNaulKaren LKL, pubmed-author:MillerDaniel JDJ, pubmed-author:MollerDavid EDE, pubmed-author:SahooSoumya PSP, pubmed-author:WangPei-ranPR, pubmed-author:WrightSamuel DSD
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	15
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3347-51
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:15950464-Animals, pubmed-meshheading:15950464-Carboxylic Acids, pubmed-meshheading:15950464-Chromans, pubmed-meshheading:15950464-Cricetinae, pubmed-meshheading:15950464-Dogs, pubmed-meshheading:15950464-Dose-Response Relationship, Drug, pubmed-meshheading:15950464-Drug Design, pubmed-meshheading:15950464-Drug Evaluation, Preclinical, pubmed-meshheading:15950464-Humans, pubmed-meshheading:15950464-Hypolipidemic Agents, pubmed-meshheading:15950464-Macaca mulatta, pubmed-meshheading:15950464-Male, pubmed-meshheading:15950464-Molecular Structure, pubmed-meshheading:15950464-PPAR alpha, pubmed-meshheading:15950464-Rats, pubmed-meshheading:15950464-Rats, Sprague-Dawley, pubmed-meshheading:15950464-Species Specificity, pubmed-meshheading:15950464-Structure-Activity Relationship
pubmed:year	2005
pubmed:articleTitle	(2R)-2-methylchromane-2-carboxylic acids: discovery of selective PPARalpha agonists as hypolipidemic agents.
pubmed:affiliation	Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000 Rahway, NJ 07065, USA. hiroo_koyama@merck.com
pubmed:publicationType	Journal Article