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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-6-13
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pubmed:abstractText |
Magic Roundabout (MR; ROBO 4) is a recently discovered gene which encodes a protein that derived its name form the structural homology with the roundabout family of genes. Genes of the roundabout family comprise neuronal-specific cell surface receptors that are involved in axon guidance. MR in contrast showed endothelial specificity in vitro and in vivo using immunohistochemistry and in situ hybridisation. The putative role of MR as an endothelial analogue of Roundabout in angiogenesis makes it an attractive target for anti-angiogenic cancer therapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0169-5002
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pubmed:author |
pubmed-author:AnigeManuelaM,
pubmed-author:BoetersInaI,
pubmed-author:BurkholderIrisI,
pubmed-author:EdlerLutzL,
pubmed-author:GörnMichaelM,
pubmed-author:HossfeldDieter KurtDK,
pubmed-author:LaackEckartE,
pubmed-author:MüllerBeateB,
pubmed-author:PanseJensJ,
pubmed-author:SchefflerAntjeA,
pubmed-author:SchuchGunterG
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
71-6
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pubmed:meshHeading |
pubmed-meshheading:15949592-Adult,
pubmed-meshheading:15949592-Aged,
pubmed-meshheading:15949592-Antibodies,
pubmed-meshheading:15949592-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:15949592-Female,
pubmed-meshheading:15949592-Humans,
pubmed-meshheading:15949592-Lung Neoplasms,
pubmed-meshheading:15949592-Male,
pubmed-meshheading:15949592-Middle Aged,
pubmed-meshheading:15949592-Neovascularization, Pathologic,
pubmed-meshheading:15949592-Prognosis,
pubmed-meshheading:15949592-Receptors, Cell Surface,
pubmed-meshheading:15949592-Survival Analysis,
pubmed-meshheading:15949592-Treatment Outcome
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pubmed:year |
2005
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pubmed:articleTitle |
Serum levels of Magic Roundabout protein in patients with advanced non-small cell lung cancer (NSCLC).
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pubmed:affiliation |
Department of Oncology and Hematology, University Hospital Hamburg-Eppendorf, Germany. goern@uke.uni-hamburg.de
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pubmed:publicationType |
Journal Article
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