| pubmed-article:15948217 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15948217 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:15948217 | lifeskim:mentions | umls-concept:C1325725 | lld:lifeskim |
| pubmed-article:15948217 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:15948217 | lifeskim:mentions | umls-concept:C0442118 | lld:lifeskim |
| pubmed-article:15948217 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:15948217 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:15948217 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15948217 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:15948217 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:15948217 | pubmed:dateCreated | 2005-7-6 | lld:pubmed |
| pubmed-article:15948217 | pubmed:abstractText | Virus-like particles containing the rotavirus (RV) internal proteins VP2 and VP6 (2/6-VLP) have been shown to induce serum and fecal antibodies as well as protection in mice after intranasal administration with a mutant of E. coli toxin, LT-R192G. To better understand the origin of fecal IgA induced by this protocol, we studied the RV-specific B cell response in systemic and mucosal lymphoid tissues using a flow cytometry assay that allows quantification and phenotypic characterization of RV-specific B lymphocytes. We also assessed the RV-specific antibody-secreting cells in the spleen and intestinal lamina propria (ILP). A remarkably high frequency of RV-specific B cells was found in the respiratory lymphoid tissues and spleen, of which only a minority expressed the alpha4beta7 integrin (intestinal homing receptor). In contrast, but in accordance with alpha4beta7 expression at the induction site, a very low response was observed in intestinal lymphoid tissues (mesenteric lymph nodes and ILP), which did not increase after a second immunization. Thus, intranasal immunization with a nonreplicating antigen does not induce an important number of RV-specific B cells with an intestinal homing profile. | lld:pubmed |
| pubmed-article:15948217 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15948217 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15948217 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15948217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15948217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15948217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15948217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15948217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15948217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15948217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15948217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15948217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15948217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15948217 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15948217 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15948217 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:15948217 | pubmed:author | pubmed-author:FrancoManuel... | lld:pubmed |
| pubmed-article:15948217 | pubmed:author | pubmed-author:CohenJeanJ | lld:pubmed |
| pubmed-article:15948217 | pubmed:author | pubmed-author:CharpilienneA... | lld:pubmed |
| pubmed-article:15948217 | pubmed:author | pubmed-author:PothierPierre... | lld:pubmed |
| pubmed-article:15948217 | pubmed:author | pubmed-author:KohliEvelyneE | lld:pubmed |
| pubmed-article:15948217 | pubmed:author | pubmed-author:OgierAgatheA | lld:pubmed |
| pubmed-article:15948217 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15948217 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:15948217 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15948217 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15948217 | pubmed:pagination | 2122-30 | lld:pubmed |
| pubmed-article:15948217 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15948217 | pubmed:meshHeading | pubmed-meshheading:15948217... | lld:pubmed |
| pubmed-article:15948217 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15948217 | pubmed:articleTitle | Distribution and phenotype of murine rotavirus-specific B cells induced by intranasal immunization with 2/6 virus-like particles. | lld:pubmed |
| pubmed-article:15948217 | pubmed:affiliation | Microbiologie Médicale et Moléculaire, EA562, UFRs Médecine et Pharmacie, Laboratoire de Virologie CHU, Dijon, France. | lld:pubmed |
| pubmed-article:15948217 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15948217 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15948217 | lld:pubmed |
