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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2005-7-25
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pubmed:abstractText |
Two isomers of the hexahydro-tetraazaacenaphthylene templates (1 and 2) are presented as novel, potent, and selective corticotropin releasing factor-1 (CRF1) receptor antagonists. In this paper, we report the affinity and SAR of a series of compounds, as well as pharmacokinetic characterization of a chosen set. The anxiolitic activity of a selected example (2ba) in the rat pup vocalization model is also presented.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:ArbanRR,
pubmed-author:BernasconiGG,
pubmed-author:CastiglioniEE,
pubmed-author:ContiniSS,
pubmed-author:Di FabioRR,
pubmed-author:DonathEE,
pubmed-author:FazzolariEE,
pubmed-author:GentileGG,
pubmed-author:GhirlandoRR,
pubmed-author:MarchionniCC,
pubmed-author:MessinaFF,
pubmed-author:MichelsLL,
pubmed-author:PasquarelloAA,
pubmed-author:PavoneFF,
pubmed-author:SabbatiniF MFM,
pubmed-author:St-DenisYY,
pubmed-author:VitulliGG,
pubmed-author:ZamporiM GMG
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3713-6
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pubmed:meshHeading |
pubmed-meshheading:15946843-Acenaphthenes,
pubmed-meshheading:15946843-Animals,
pubmed-meshheading:15946843-Anxiety,
pubmed-meshheading:15946843-Depression,
pubmed-meshheading:15946843-Disease Models, Animal,
pubmed-meshheading:15946843-Drug Evaluation, Preclinical,
pubmed-meshheading:15946843-Molecular Structure,
pubmed-meshheading:15946843-Rats,
pubmed-meshheading:15946843-Rats, Wistar,
pubmed-meshheading:15946843-Receptors, Corticotropin-Releasing Hormone,
pubmed-meshheading:15946843-Structure-Activity Relationship
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pubmed:year |
2005
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pubmed:articleTitle |
Substituted tetraazaacenaphthylenes as potent CRF1 receptor antagonists for the treatment of depression and anxiety.
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pubmed:affiliation |
Department of Medicinal Chemistry, GlaxoSmithKline Medicines Research Center, Via A. Fleming 4, 37135 Verona, Italy. yves.a.stdenis@gsk.com
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pubmed:publicationType |
Journal Article
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