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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-6-10
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pubmed:abstractText |
Coagulation factor VIII (FVIII) is a heavily glycosylated heterodimeric plasma protein that consists of a heavy (domains A1-A2-B) and light chain (domains A3-C1-C2). It has been well established that the clearance of FVIII from the circulation involves mechanisms that are sensitive to the low-density lipoprotein receptor (LDLR) family antagonist receptor-associated protein (RAP), including LDLR-related protein. Because FVIII clearance in the presence of a bolus injection of RAP still occurs fairly efficient, also RAP-independent mechanisms are likely to be involved.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1538-7933
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1257-65
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15946216-Animals,
pubmed-meshheading:15946216-Asialoglycoprotein Receptor,
pubmed-meshheading:15946216-Binding Sites,
pubmed-meshheading:15946216-Calcium,
pubmed-meshheading:15946216-Carbohydrates,
pubmed-meshheading:15946216-Factor VIII,
pubmed-meshheading:15946216-Galactose,
pubmed-meshheading:15946216-Glycosylation,
pubmed-meshheading:15946216-Humans,
pubmed-meshheading:15946216-Male,
pubmed-meshheading:15946216-Metabolic Clearance Rate,
pubmed-meshheading:15946216-Mice,
pubmed-meshheading:15946216-Mice, Inbred C57BL,
pubmed-meshheading:15946216-Protein Binding,
pubmed-meshheading:15946216-Protein Structure, Tertiary,
pubmed-meshheading:15946216-Protein Subunits,
pubmed-meshheading:15946216-Surface Plasmon Resonance
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pubmed:year |
2005
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pubmed:articleTitle |
The B domain of coagulation factor VIII interacts with the asialoglycoprotein receptor.
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pubmed:affiliation |
Department of Plasma Proteins, Sanquin Research at CLB, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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