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rdf:type |
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lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0034693,
umls-concept:C0038838,
umls-concept:C0041242,
umls-concept:C0129975,
umls-concept:C0205263,
umls-concept:C0205341,
umls-concept:C0267952,
umls-concept:C0392756,
umls-concept:C0442027,
umls-concept:C1999216
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pubmed:issue |
6
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pubmed:dateCreated |
2005-6-10
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pubmed:abstractText |
An oral trypsin inhibitor, camostat (CM), has a beneficial effect on chronic pancreatitis, but its mechanism is not yet fully understood. Recently, pancreatic stellate cells (PSC) have been reported to play an essential role in pancreatic fibrosis. An experimental model of pancreatic fibrosis induced by a superoxide dismutase (SOD) inhibitor (diethyldithiocarbamate [DDC]) was developed in rats. Thus, the effect of an oral trypsin inhibitor on pancreatic fibrosis and PSC was investigated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0815-9319
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2005 Blackwell Publishing Asia Pty Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
20
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
895-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15946137-Administration, Oral,
pubmed-meshheading:15946137-Animals,
pubmed-meshheading:15946137-Disease Models, Animal,
pubmed-meshheading:15946137-Ditiocarb,
pubmed-meshheading:15946137-Drug Administration Schedule,
pubmed-meshheading:15946137-Fibrosis,
pubmed-meshheading:15946137-Gabexate,
pubmed-meshheading:15946137-Male,
pubmed-meshheading:15946137-Pancreas,
pubmed-meshheading:15946137-Pancreatic Diseases,
pubmed-meshheading:15946137-Procollagen-Proline Dioxygenase,
pubmed-meshheading:15946137-Rats,
pubmed-meshheading:15946137-Rats, Wistar,
pubmed-meshheading:15946137-Severity of Illness Index,
pubmed-meshheading:15946137-Treatment Outcome,
pubmed-meshheading:15946137-Trypsin Inhibitors
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pubmed:year |
2005
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pubmed:articleTitle |
Camostat, an oral trypsin inhibitor, reduces pancreatic fibrosis induced by repeated administration of a superoxide dismutase inhibitor in rats.
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pubmed:affiliation |
Department of Laboratory Medicine, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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