| pubmed-article:15944770 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15944770 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15944770 | lifeskim:mentions | umls-concept:C0007134 | lld:lifeskim |
| pubmed-article:15944770 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:15944770 | lifeskim:mentions | umls-concept:C0003695 | lld:lifeskim |
| pubmed-article:15944770 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:15944770 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:15944770 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:15944770 | lifeskim:mentions | umls-concept:C1289971 | lld:lifeskim |
| pubmed-article:15944770 | lifeskim:mentions | umls-concept:C2917177 | lld:lifeskim |
| pubmed-article:15944770 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:15944770 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15944770 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15944770 | pubmed:dateCreated | 2005-6-9 | lld:pubmed |
| pubmed-article:15944770 | pubmed:abstractText | The metabolism of arachidonic acid by either the cyclooxygenase or lipoxygenase (LOX) pathway is believed to play an important role in tumor promotion. We investigated the expression of 5- and 12-LOX in renal cell carcinoma (RCC), as well as the effects of their inhibitors on cell proliferation in 2 RCC cell lines (Caki-1 and A498). Expression of 5- and 12-LOX was detected by immunohistochemistry and RT-PCR. Effects of LOX inhibitors on RCC cell growth were examined by MTT assay, and Hoechst staining was used to determine whether or not the LOX inhibitors induce apoptosis. While 5- and 12-LOX expression levels were slightly detected in NK tissues, marked expressions of 5- and 12-LOX were detected in RCC tissues. 5-LOX inhibitors caused marked reduction of RCC cells in a concentration- and time-dependent manner. The effect of the 5-LOX inhibitor was stronger than the 12-LOX inhibitor. Furthermore, the 5-LOX inhibitor caused a marked reduction of RCC cells through apoptosis. LOX, especially 5-LOX, is induced in RCC, and the results suggest that the 5-LOX inhibitor may mediate potent anti-proliferative effects against RCC cells. Thus, 5-LOX may become a new target in treatment of RCC. | lld:pubmed |
| pubmed-article:15944770 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15944770 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15944770 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15944770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15944770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15944770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15944770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15944770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15944770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15944770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15944770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15944770 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15944770 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15944770 | pubmed:issn | 1021-335X | lld:pubmed |
| pubmed-article:15944770 | pubmed:author | pubmed-author:TsuchidaKenji... | lld:pubmed |
| pubmed-article:15944770 | pubmed:author | pubmed-author:TakemotoYoshi... | lld:pubmed |
| pubmed-article:15944770 | pubmed:author | pubmed-author:SanoHajimeH | lld:pubmed |
| pubmed-article:15944770 | pubmed:author | pubmed-author:YoshimuraRiki... | lld:pubmed |
| pubmed-article:15944770 | pubmed:author | pubmed-author:NakataniTatsu... | lld:pubmed |
| pubmed-article:15944770 | pubmed:author | pubmed-author:KawahitoYutak... | lld:pubmed |
| pubmed-article:15944770 | pubmed:author | pubmed-author:MitsuhashiMak... | lld:pubmed |
| pubmed-article:15944770 | pubmed:author | pubmed-author:MatsuyamaMasa... | lld:pubmed |
| pubmed-article:15944770 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15944770 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:15944770 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15944770 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15944770 | pubmed:pagination | 73-9 | lld:pubmed |
| pubmed-article:15944770 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:15944770 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15944770 | pubmed:articleTitle | 5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway. | lld:pubmed |
| pubmed-article:15944770 | pubmed:affiliation | Department of Urology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. | lld:pubmed |
| pubmed-article:15944770 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15944770 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15944770 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15944770 | lld:pubmed |
