| pubmed-article:1594453 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1594453 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:1594453 | lifeskim:mentions | umls-concept:C0006668 | lld:lifeskim |
| pubmed-article:1594453 | lifeskim:mentions | umls-concept:C0006669 | lld:lifeskim |
| pubmed-article:1594453 | lifeskim:mentions | umls-concept:C0015295 | lld:lifeskim |
| pubmed-article:1594453 | lifeskim:mentions | umls-concept:C0002345 | lld:lifeskim |
| pubmed-article:1594453 | lifeskim:mentions | umls-concept:C0242210 | lld:lifeskim |
| pubmed-article:1594453 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:1594453 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:1594453 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:1594453 | pubmed:dateCreated | 1992-6-30 | lld:pubmed |
| pubmed-article:1594453 | pubmed:abstractText | Transcripts derived from the 6 exon CALC I gene are differentially processed in a tissue-specific fashion to include or exclude a calcitonin-specific exon 4. All cell types which transcribe a second calcitonin/CGRP gene, CALC II, exclude exon 4. Substitution of the first 30 nucleotides of CALC I exon 4 with analogous CALC II sequence was sufficient to prevent recognition of exon 4 in in vitro or in vivo RNA splicing systems. UV crosslinking detected a approximately 66 kDa RNA-binding protein in HeLa nuclear extract which interacted with CALC I proximal exon sequence, but not CALC II or mutant sequences. UV crosslinking of this protein was inhibited by addition of nuclear extract from a cell type which normally causes exclusion of exon 4. These results identify an important regulatory element within exon 4 and support a model in which calcitonin production requires protein interaction with this sequence to facilitate exon recognition. | lld:pubmed |
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| pubmed-article:1594453 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1594453 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1594453 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1594453 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1594453 | pubmed:month | May | lld:pubmed |
| pubmed-article:1594453 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:1594453 | pubmed:author | pubmed-author:PelegSS | lld:pubmed |
| pubmed-article:1594453 | pubmed:author | pubmed-author:BergenS SSS | lld:pubmed |
| pubmed-article:1594453 | pubmed:author | pubmed-author:GagelR FRF | lld:pubmed |
| pubmed-article:1594453 | pubmed:author | pubmed-author:CoteG JGJ | lld:pubmed |
| pubmed-article:1594453 | pubmed:author | pubmed-author:StolowD TDT | lld:pubmed |
| pubmed-article:1594453 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1594453 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:1594453 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:1594453 | pubmed:geneSymbol | CALC I | lld:pubmed |
| pubmed-article:1594453 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1594453 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1594453 | pubmed:pagination | 2361-6 | lld:pubmed |
| pubmed-article:1594453 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1594453 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1594453 | pubmed:articleTitle | Identification of exon sequences and an exon binding protein involved in alternative RNA splicing of calcitonin/CGRP. | lld:pubmed |
| pubmed-article:1594453 | pubmed:affiliation | Department of Medicine, Baylor College of Medicine, Houston, TX 77030. | lld:pubmed |
| pubmed-article:1594453 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1594453 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1594453 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:1594453 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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