Linked Life Data

15944215

Source:http://linkedlifedata.com/resource/pubmed/id/15944215

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2005-10-21
pubmed:abstractText
Pancreaticobiliary maljunction (PBM) is a high risk factor in biliary tract carcinoma. The chemopreventive action of a cyclooxygenase (COX)-2 inhibitor (meloxicam) on N-nitrosobis (2-oxopropyl) amine (BOP)-induced gallbladder cancer in hamster PBM models was investigated. In 7-week-old female Syrian golden hamsters, the extrahepatic bile duct at the distal end of the common duct was ligated and cholecystoduodenostomy was performed (group I). In group II, the same surgery was performed and from week 4 after surgery, 10 mg/kg of BOP was injected subcutaneously once a week with a 1-week interval. In group III, in addition to the measures employed in group II, 5 mg/kg/day of meloxicam was administered once a day, every weekday. Pathological findings in the gallbladder in week 20 after surgery were as follows. In group I, proper epithelium (PE) was predominant and there was no cancer. In group II, PE was predominant, but there was also hyperplasia and atypical epithelium (AE) recognized in 8 of 11 cases (72.7%); the area of AE was more extensive than that in group I. Carcinoma in situ (CIS) was recognized in 4 of 11 cases (36.4%) in group II. Group III showed the same pathological findings as group I. However, compared with group II, the incidence of AE decreased to 27.3% and no cancerous lesion was observed. In week 20 after surgery, the proliferative cell nuclear antigen labeling index in group III was statistically significantly lower than in group II (P = 0.045). No statistically significant differences were noted among the groups in terms of apoptosis labeling index in week 20 after surgery. In conclusion, it was confirmed that meloxicam suppresses carcinogenesis in hamster PBM models and its mechanism may be based on the suppression of cell growth.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0143-3334
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1922-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15944215-Animals, pubmed-meshheading:15944215-Apoptosis, pubmed-meshheading:15944215-Carcinogens, pubmed-meshheading:15944215-Carcinoma in Situ, pubmed-meshheading:15944215-Cell Proliferation, pubmed-meshheading:15944215-Cell Transformation, Neoplastic, pubmed-meshheading:15944215-Cricetinae, pubmed-meshheading:15944215-Cyclooxygenase 2, pubmed-meshheading:15944215-Cyclooxygenase Inhibitors, pubmed-meshheading:15944215-Disease Models, Animal, pubmed-meshheading:15944215-Epithelium, pubmed-meshheading:15944215-Female, pubmed-meshheading:15944215-Gallbladder, pubmed-meshheading:15944215-Gallbladder Neoplasms, pubmed-meshheading:15944215-Hyperplasia, pubmed-meshheading:15944215-Mesocricetus, pubmed-meshheading:15944215-Nitrosamines, pubmed-meshheading:15944215-Proliferating Cell Nuclear Antigen, pubmed-meshheading:15944215-Thiazines, pubmed-meshheading:15944215-Thiazoles
pubmed:year
2005
pubmed:articleTitle
Inhibitory effect of meloxicam, a cyclooxygenase-2 inhibitor, on N-nitrosobis (2-oxopropyl) amine induced biliary carcinogenesis in Syrian hamsters.
pubmed:affiliation
Third Department of Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan. akibobo@hotmail.com
pubmed:publicationType
Journal Article, Comparative Study