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rdf:type |
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lifeskim:mentions |
umls-concept:C0009247,
umls-concept:C0010137,
umls-concept:C0024091,
umls-concept:C0029433,
umls-concept:C0175630,
umls-concept:C0177804,
umls-concept:C0206015,
umls-concept:C0332281,
umls-concept:C0339510,
umls-concept:C0441889,
umls-concept:C0917713,
umls-concept:C1414083,
umls-concept:C1826421,
umls-concept:C2699549
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pubmed:issue |
6
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pubmed:dateCreated |
2005-6-9
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pubmed:abstractText |
Cortisone is an endogenous corticosteroid that has negligible intrinsic glucocorticoid activity but can be converted to the active corticosteroid cortisol by the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). 11beta-HSD1 is expressed in osteoblasts and may play a role in determining susceptibility to glucocorticoid-induced osteoporosis. In intact osteoblasts enzyme activity, and thus cortisol generation, is dependent on substrate concentration with an almost linear increase in activity across the physiological range. We have therefore attempted to measure the impact of 11beta-HSD1 activity on bone in vivo by examining the association of circulating cortisone with bone markers, bone mineral density (BMD) and bone loss in a cohort of women and men.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0300-0664
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
692-7
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pubmed:dateRevised |
2007-8-13
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pubmed:meshHeading |
pubmed-meshheading:15943831-Aged,
pubmed-meshheading:15943831-Biological Markers,
pubmed-meshheading:15943831-Bone Density,
pubmed-meshheading:15943831-Bone Remodeling,
pubmed-meshheading:15943831-Collagen,
pubmed-meshheading:15943831-Collagen Type I,
pubmed-meshheading:15943831-Cortisone,
pubmed-meshheading:15943831-Cross-Sectional Studies,
pubmed-meshheading:15943831-Female,
pubmed-meshheading:15943831-Follow-Up Studies,
pubmed-meshheading:15943831-Humans,
pubmed-meshheading:15943831-Hydrocortisone,
pubmed-meshheading:15943831-Linear Models,
pubmed-meshheading:15943831-Male,
pubmed-meshheading:15943831-Middle Aged,
pubmed-meshheading:15943831-Osteocalcin,
pubmed-meshheading:15943831-Peptides,
pubmed-meshheading:15943831-Sex Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Circulating cortisone levels are associated with biochemical markers of bone formation and lumbar spine BMD: the Hertfordshire Cohort Study.
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pubmed:affiliation |
Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK. M.S.Cooper@bham.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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