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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-6-9
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787487,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787488,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787489,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787490,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787491,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787492,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787493,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787494,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787495,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787496,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787497,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787498,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787499,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787500,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787501,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787502,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787503,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787504,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787505,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787506,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787507,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787508,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787509,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787510,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787511,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787512,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787513,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787514,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787515,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787516,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787517,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787518,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787519,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787520,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787521,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787522,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787523,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787524,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787525,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787526,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787527,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787528,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787529,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787530,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787531,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787532,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787533,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787534,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787535,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY787536
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pubmed:abstractText |
Most studies of HIV-1 drug resistance have examined subtype B viruses; fewer data are available from developing countries, where non-B subtypes predominate. We determined the prevalence of mutations at protease and reverse transcriptase drug resistance positions in antiretroviral drug-naive individuals in southern India. The pol region of the genome was amplified from plasma HIV-1 RNA in 50 patients. All sequences clustered with HIV-1 subtype C. All patients had at least one protease and/or RT mutation at a known subtype B drug resistance position. Twenty percent of patients had mutations at major protease inhibitor resistance positions and 100% had mutations at minor protease inhibitor resistance positions. Six percent and 14% of patients had mutations at nucleoside reverse transcriptase inhibitor and/or nonnucleoside reverse transcriptase inhibitor resistance positions, respectively. Larger scale studies need to be undertaken to better define the genotypic variation of circulating Indian subtype C viruses and their potential impact on drug susceptibility and clinical outcome in treated individuals.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0889-2229
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
301-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15943572-Humans,
pubmed-meshheading:15943572-Mutation,
pubmed-meshheading:15943572-Female,
pubmed-meshheading:15943572-Male,
pubmed-meshheading:15943572-India,
pubmed-meshheading:15943572-Adult,
pubmed-meshheading:15943572-Middle Aged,
pubmed-meshheading:15943572-Base Sequence,
pubmed-meshheading:15943572-RNA, Viral,
pubmed-meshheading:15943572-Polymorphism, Genetic,
pubmed-meshheading:15943572-Molecular Sequence Data
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