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rdf:type |
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lifeskim:mentions |
umls-concept:C0017351,
umls-concept:C0034897,
umls-concept:C0243095,
umls-concept:C0439855,
umls-concept:C0580822,
umls-concept:C1335193,
umls-concept:C1511695,
umls-concept:C1515021,
umls-concept:C1516520,
umls-concept:C1547300,
umls-concept:C1548760,
umls-concept:C1550594
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pubmed:issue |
2
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pubmed:dateCreated |
2005-8-8
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pubmed:abstractText |
We present an extensive characterization of 10 B-cell lymphomas with a t(9;14)(p13;q32). The presence of the PAX5/IGH gene rearrangement was demonstrated by fluorescence in situ hybridization (FISH) using a validated probe set, whereas complex karyotypic changes were reassessed by multiplex-FISH (M-FISH). Pathologic and clinical review revealed the presence of this rearrangement in 4 histiocyte-rich, T-cell-rich B-cell lymphomas (HRTR-BCLs) and 2 posttransplantation diffuse large B-cell lymphomas (PTLD-DLBCLs). In contrast to initial observations describing this translocation in lymphoplasmacytic lymphoma (LPL) and LPL-derived large B-cell lymphoma, our data showed a wide morphologic and clinical spectrum associated with the PAX5/IGH rearrangement, pointing to an association between this aberration and a subset of de novo DLBCLs presenting with advanced disease and adverse prognosis. In addition, the recurrent incidence of this rearrangement in both HRTR-BCL (4 cases) and PTLD-DLBCL (2 cases) was previously unrecognized and is intriguing.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1045-2257
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pubmed:author |
pubmed-author:BastardChristianC,
pubmed-author:CavazziniFrancescoF,
pubmed-author:DastugueNicoleN,
pubmed-author:De PaepeAnneA,
pubmed-author:De PaepePascaleP,
pubmed-author:De Wolf-PeetersChrisC,
pubmed-author:HerensChristianC,
pubmed-author:MichauxLucienneL,
pubmed-author:MoreauElsE,
pubmed-author:PoppeBruceB,
pubmed-author:PraetMarleenM,
pubmed-author:SpelemanFrankF,
pubmed-author:Van LimbergenHeidiH,
pubmed-author:WlodarskaIwonaI,
pubmed-author:YigitNurtenN
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
218-23
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15942942-Aged,
pubmed-meshheading:15942942-Aged, 80 and over,
pubmed-meshheading:15942942-B-Cell-Specific Activator Protein,
pubmed-meshheading:15942942-Chromosomes, Human, Pair 14,
pubmed-meshheading:15942942-Chromosomes, Human, Pair 9,
pubmed-meshheading:15942942-DNA-Binding Proteins,
pubmed-meshheading:15942942-Female,
pubmed-meshheading:15942942-Gene Rearrangement,
pubmed-meshheading:15942942-Humans,
pubmed-meshheading:15942942-Immunoglobulin Heavy Chains,
pubmed-meshheading:15942942-Karyotyping,
pubmed-meshheading:15942942-Lymphoma, B-Cell,
pubmed-meshheading:15942942-Male,
pubmed-meshheading:15942942-Middle Aged,
pubmed-meshheading:15942942-Transcription Factors,
pubmed-meshheading:15942942-Translocation, Genetic
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pubmed:year |
2005
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pubmed:articleTitle |
PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangements.
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pubmed:affiliation |
Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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