Source:http://linkedlifedata.com/resource/pubmed/id/15942714
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2005-6-8
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pubmed:abstractText |
Dehydroepiandrosterone (DHEA) is an endogenous steroid that is synthesized mainly in the adrenal cortex; it is found in plasma as the sulfate-conjugated form (DHEA-S). Pharmacological doses of DHEA exhibit anti-proliferative effects on malignant cell lines and some tumors in experimental animals. The purpose of this study was to evaluate the effect of these steroids on proliferation in human cancer cell lines.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0944-1174
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
490-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15942714-Apoptosis,
pubmed-meshheading:15942714-Carcinoma, Hepatocellular,
pubmed-meshheading:15942714-Cell Line, Tumor,
pubmed-meshheading:15942714-Cell Proliferation,
pubmed-meshheading:15942714-Dehydroepiandrosterone,
pubmed-meshheading:15942714-Humans,
pubmed-meshheading:15942714-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:15942714-Phosphorylation,
pubmed-meshheading:15942714-Sensitivity and Specificity,
pubmed-meshheading:15942714-Signal Transduction
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pubmed:year |
2005
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pubmed:articleTitle |
Apoptosis and inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone.
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pubmed:affiliation |
Division of Gastroenterology and Hepatology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences and University Hospital, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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