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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2005-6-7
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pubmed:abstractText |
We identified cellular targets of canonical Wnt signaling within the skeleton, which included chondrocytes, osteoblasts, and osteocytes in growing bone, but only osteocytes and chondrocytes in the mature skeleton. Mechanical deformation induced Wnt signaling in osteoblasts in vitro.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0884-0431
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1103-13
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15940363-Animals,
pubmed-meshheading:15940363-Bone Development,
pubmed-meshheading:15940363-Bone and Bones,
pubmed-meshheading:15940363-Cytoskeletal Proteins,
pubmed-meshheading:15940363-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:15940363-Mice,
pubmed-meshheading:15940363-Mice, Transgenic,
pubmed-meshheading:15940363-Promoter Regions, Genetic,
pubmed-meshheading:15940363-RNA, Messenger,
pubmed-meshheading:15940363-Signal Transduction,
pubmed-meshheading:15940363-Skull,
pubmed-meshheading:15940363-Stress, Mechanical,
pubmed-meshheading:15940363-T-Lymphocytes,
pubmed-meshheading:15940363-Trans-Activators,
pubmed-meshheading:15940363-Wnt Proteins,
pubmed-meshheading:15940363-beta Catenin,
pubmed-meshheading:15940363-beta-Galactosidase
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pubmed:year |
2005
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pubmed:articleTitle |
TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro.
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pubmed:affiliation |
Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8020, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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