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pubmed:abstractText |
Although disruption of guanylyl cyclase (GC) A, a natriuretic peptide receptor, induces cardiac hypertrophy and fibrosis, the molecular mechanism underlying these effects are not well understood. In this study, we examined the role of calcineurin, a calcium-dependent phosphatase, in cardiac remodeling in GCA-knockout (GCA-KO) mice.
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pubmed:affiliation |
Department of Biochemistry, Research Institute, National Cardiovascular Center, Suita, Osaka, Japan.
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