Linked Life Data

15939336

Source:http://linkedlifedata.com/resource/pubmed/id/15939336

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-6-7
pubmed:abstractText
MAPKs are members of a three-kinase phosphorelay system composed of the MAPK, MAPK kinase (MKK) and MAPK kinase kinase (MKKK). MKKKs phosphorylate and activate MKKs, which in turn phosphorylate and activate MAPKs. Scaffolding proteins organize MKK-MAPK complexes for activation by specific MKKKs and do so in specific locations in the cell. It is the MKKK associated with the scaffolded complex that provides selectivity for activation by upstream stimuli including GTPases, additional kinases and receptors. The demonstration that specific MKKKs also exert control over gene expression by regulating the repertoire of required transcriptional machinery is a newly recognized function for MKKKs. Appreciation of MKKKs as signaling hubs for selectively integrating different upstream stimuli into the control of MAPK networks, and the ability of MKKKs to function as master planners of the transcription factor machinery suggest that MKKK inhibitors will provide selective therapeutic intervention of stimulus-specific MAPK responses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1367-5931
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
325-31
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression.
pubmed:affiliation
Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, NC 27599-7365, USA. gary_johnson@med.unc.edu
pubmed:publicationType
Journal Article, Review