Linked Life Data

15939091

Source:http://linkedlifedata.com/resource/pubmed/id/15939091

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-6-7
pubmed:abstractText
An epigenetic key protein MeCP2 is thought to be expressed exclusively in mature neurons. Here, we show that MeCP2 is expressed in embryonic non-neuronal cells by immunocytochemistry and Western blotting, and that knockdown of MeCP2 levels using RNA interference reduces their proliferation. These findings suggest that MeCP2 is essential to non-neuronal cell growth during brain development, which may be associated with microcephaly of Rett syndrome patients with MeCP2 mutations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
157
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15939091-Animals, pubmed-meshheading:15939091-Blotting, Western, pubmed-meshheading:15939091-Bromodeoxyuridine, pubmed-meshheading:15939091-Cell Count, pubmed-meshheading:15939091-Cell Fractionation, pubmed-meshheading:15939091-Cell Proliferation, pubmed-meshheading:15939091-Cells, Cultured, pubmed-meshheading:15939091-Cerebral Cortex, pubmed-meshheading:15939091-Chromosomal Proteins, Non-Histone, pubmed-meshheading:15939091-DNA-Binding Proteins, pubmed-meshheading:15939091-Embryo, Mammalian, pubmed-meshheading:15939091-Gene Expression Regulation, Developmental, pubmed-meshheading:15939091-Glial Fibrillary Acidic Protein, pubmed-meshheading:15939091-Immunohistochemistry, pubmed-meshheading:15939091-Methyl-CpG-Binding Protein 2, pubmed-meshheading:15939091-Mice, pubmed-meshheading:15939091-Mice, Knockout, pubmed-meshheading:15939091-Microtubule-Associated Proteins, pubmed-meshheading:15939091-Neuroglia, pubmed-meshheading:15939091-RNA, Small Interfering, pubmed-meshheading:15939091-Repressor Proteins, pubmed-meshheading:15939091-Rett Syndrome, pubmed-meshheading:15939091-Time Factors
pubmed:year
2005
pubmed:articleTitle
A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth.
pubmed:affiliation
Department of Epigenetic Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Tamaho, Yamanashi, 409-3898, Japan. kaoru@yamanashi.ac.jp
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't