Source:http://linkedlifedata.com/resource/pubmed/id/15938041
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2005-6-6
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| pubmed:abstractText |
Type 2 diabetes is frequently associated with an inflammatory status; the relationships between low-grade inflammation and diabetic nephropathy are still unclear. The aim of this study was to evaluate the relationships between acute-phase markers of inflammation, glomerular structure, and albumin excretion rate (AER) in type 2 diabetes. In 74 patients with type 2 diabetes (23 normoalbuminuric, 30 microalbuminuric, and 21 proteinuric) fibrinogen, serum amyloid A protein (SAA), C-reactive protein (CRP), and IL-6 were determined. AER was measured on three 24-h urine collections; GFR was measured by 51Cr EDTA plasma clearance. A kidney biopsy was performed, and mesangial fractional volume [Vv(mes/glom)] and glomerular basement membrane (GBM) width were estimated by electron microscopic morphometric analysis. CRP, fibrinogen, SAA, and IL-6 differed among groups, with proteinuric patients having the highest levels. SAA and fibrinogen correlated with AER (P < 0.03 and P < 0.001, respectively). GBM width and Vv(mes/glom) increased from normoalbuminuric to proteinuric patients [P < 0.005 normoalbuminuric and microalbuminuric versus proteinuric for GBM, P < 0.01 normoalbuminuric versus proteinuric for Vv(mes/glom)]. In patients with increased GBM width (> 396 nm), CRP, SAA, and IL-6 were higher than in patients with normal GBM width (P < 0.003, P < 0.004, and P < 0.0004, respectively). GBM width was directly correlated with fibrinogen (r = 0.33, P < 0.002) and IL-6 (r = 0.25 P < 0.05). In conclusion, this study demonstrates that acute-phase markers of inflammation are associated with nephropathy status and GBM thickening, suggesting a role for inflammation in the pathogenesis of diabetic glomerulopathy.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1046-6673
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
16 Suppl 1
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
S78-82
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15938041-Acute Disease,
pubmed-meshheading:15938041-Aged,
pubmed-meshheading:15938041-Albuminuria,
pubmed-meshheading:15938041-Analysis of Variance,
pubmed-meshheading:15938041-Biological Markers,
pubmed-meshheading:15938041-C-Reactive Protein,
pubmed-meshheading:15938041-Case-Control Studies,
pubmed-meshheading:15938041-Diabetes Mellitus, Type 2,
pubmed-meshheading:15938041-Diabetic Nephropathies,
pubmed-meshheading:15938041-Disease Progression,
pubmed-meshheading:15938041-Female,
pubmed-meshheading:15938041-Glomerular Filtration Rate,
pubmed-meshheading:15938041-Humans,
pubmed-meshheading:15938041-Inflammation Mediators,
pubmed-meshheading:15938041-Interleukin-6,
pubmed-meshheading:15938041-Kidney Glomerulus,
pubmed-meshheading:15938041-Male,
pubmed-meshheading:15938041-Middle Aged,
pubmed-meshheading:15938041-Probability,
pubmed-meshheading:15938041-Prognosis,
pubmed-meshheading:15938041-Reference Values,
pubmed-meshheading:15938041-Risk Assessment,
pubmed-meshheading:15938041-Sensitivity and Specificity,
pubmed-meshheading:15938041-Severity of Illness Index,
pubmed-meshheading:15938041-Statistics, Nonparametric
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| pubmed:year |
2005
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| pubmed:articleTitle |
Acute-phase markers of inflammation and glomerular structure in patients with type 2 diabetes.
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| pubmed:affiliation |
Department of Medical and Surgical Sciences, University of Padova Medical School, Padova, Italy.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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