Source:http://linkedlifedata.com/resource/pubmed/id/15937940
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2005-6-29
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| pubmed:abstractText |
We analyzed genetic variations of angiotensin-converting enzyme 2 (ACE2), considering that it might influence patients' susceptibility to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) or development of SARS as a functional receptor. By cloning of the full-length cDNA of the ACE2 gene in the lung, where replication occurs on SARS-CoV, it was shown that there are different splicing sites. All exons including the new alternative exon, exon-intron boundaries, and the corresponding 5'-flanking region of the gene were investigated and 19 single nucleotide polymorphisms (SNPs) were found. Out of these, 13 SNPs including one non-synonymous substitution and three 3'-UTR polymorphisms were newly identified. A case control study involving 44 SARS cases, 16 anti-SARS-CoV antibody-positive contacts, 87 antibody-negative contacts, and 50 non-contacts in Vietnam, failed to obtain any evidence that the ACE2 gene polymorphisms are involved in the disease process in the population. Nevertheless, identification of new 5'-untranslated exon and new SNPs is considered helpful in investigating regulation of ACE2 gene expression in the future.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
|
| pubmed:issn |
1552-4825
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| pubmed:author |
pubmed-author:BanVo VanVV,
pubmed-author:HaLe DangLD,
pubmed-author:HijikataMinakoM,
pubmed-author:ItoyamaSatoruS,
pubmed-author:KeichoNaotoN,
pubmed-author:KirikaeFumikoF,
pubmed-author:KirikaeTeruoT,
pubmed-author:KuratsujiTadatoshiT,
pubmed-author:LongHoang ThuyHT,
pubmed-author:MatsushitaIkumiI,
pubmed-author:PhiNguyen ChiNC,
pubmed-author:PughA WAW,
pubmed-author:SasazukiTakehikoT,
pubmed-author:YanaiHidekiH
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| pubmed:copyrightInfo |
Copyright (c) 2005 Wiley-Liss, Inc.
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| pubmed:issnType |
Print
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| pubmed:day |
1
|
| pubmed:volume |
136
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
52-7
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| pubmed:dateRevised |
2009-7-27
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| pubmed:meshHeading |
pubmed-meshheading:15937940-5' Flanking Region,
pubmed-meshheading:15937940-Adolescent,
pubmed-meshheading:15937940-Adult,
pubmed-meshheading:15937940-Aged,
pubmed-meshheading:15937940-Alleles,
pubmed-meshheading:15937940-Alternative Splicing,
pubmed-meshheading:15937940-Carboxypeptidases,
pubmed-meshheading:15937940-Case-Control Studies,
pubmed-meshheading:15937940-Exons,
pubmed-meshheading:15937940-Female,
pubmed-meshheading:15937940-Gene Frequency,
pubmed-meshheading:15937940-Genotype,
pubmed-meshheading:15937940-Humans,
pubmed-meshheading:15937940-Male,
pubmed-meshheading:15937940-Middle Aged,
pubmed-meshheading:15937940-Peptidyl-Dipeptidase A,
pubmed-meshheading:15937940-Polymorphism, Genetic,
pubmed-meshheading:15937940-Polymorphism, Single Nucleotide,
pubmed-meshheading:15937940-Severe Acute Respiratory Syndrome,
pubmed-meshheading:15937940-Vietnam
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| pubmed:year |
2005
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| pubmed:articleTitle |
Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene: lack of association with SARS in the Vietnamese population.
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| pubmed:affiliation |
Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, Tokyo, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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