Source:http://linkedlifedata.com/resource/pubmed/id/15937505
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2005-7-18
|
| pubmed:abstractText |
We conducted a nation-wide survey of 112 adult Japanese patients who underwent reduced-intensity stem cell transplantation (RIST) from 1999 to 2002. Underlying diseases included indolent (n=45), aggressive (n=58) and highly aggressive lymphomas (n=9). Median age of the patients was 49 years. A total of 40 patients (36%) had relapsed diseases after autologous stem cell transplantation and 36 patients (32%) had received radiotherapy. RIST regimens were fludarabine-based (n=95), low-dose total body irradiation-based (n=6) and others (n=11). Cumulative incidences of grade II-IV acute graft-versus-host disease (GVHD) and chronic GVHD were, respectively, 49 and 59%. Cumulative incidences of progression and progression-free mortality were 18 and 25%, respectively. With a median follow-up of 23.9 months, 3-year overall survival rates were 59%. A multivariate analysis identified three significant factors for progression, which are history of radiation (relative risk (RR) 3.45, confidential interval (CI) 1.12-10.0, P=0.03), central nervous system involvement (RR 6.25, CI 2.08-20.0, P=0.001) and development of GVHD (RR 0.28, CI 0.090-0.86, P=0.026). RIST may have decreased the rate of transplant-related mortality, and GVHD may have induced a graft-versus-lymphoma effect. However, whether or not these potential benefits can be directly translated into improved patient survival should be evaluated in further studies.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0268-3369
|
| pubmed:author |
pubmed-author:KammII,
pubmed-author:KandaYY,
pubmed-author:KishiYY,
pubmed-author:KusumiEE,
pubmed-author:MoriTT,
pubmed-author:MurashigeNN,
pubmed-author:MutaKK,
pubmed-author:OgawaHH,
pubmed-author:SuzukiRR,
pubmed-author:TakaueYY,
pubmed-author:TakeuchiKK,
pubmed-author:TamakiTT,
pubmed-author:TanakaYY,
pubmed-author:TaniguchiSS,
pubmed-author:TanimotoT ETE,
pubmed-author:YamaneTT
|
| pubmed:issnType |
Print
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
205-13
|
| pubmed:meshHeading |
pubmed-meshheading:15937505-Adult,
pubmed-meshheading:15937505-Aged,
pubmed-meshheading:15937505-Disease-Free Survival,
pubmed-meshheading:15937505-Female,
pubmed-meshheading:15937505-Graft vs Host Disease,
pubmed-meshheading:15937505-Graft vs Tumor Effect,
pubmed-meshheading:15937505-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:15937505-Humans,
pubmed-meshheading:15937505-Japan,
pubmed-meshheading:15937505-Lymphoma,
pubmed-meshheading:15937505-Male,
pubmed-meshheading:15937505-Middle Aged,
pubmed-meshheading:15937505-Multivariate Analysis,
pubmed-meshheading:15937505-Retrospective Studies,
pubmed-meshheading:15937505-Risk,
pubmed-meshheading:15937505-Stem Cell Transplantation,
pubmed-meshheading:15937505-Time Factors,
pubmed-meshheading:15937505-Treatment Outcome
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Reduced-intensity hematopoietic stem-cell transplantation for malignant lymphoma: a retrospective survey of 112 adult patients in Japan.
|
| pubmed:affiliation |
Department of Hematology, Toranomon Hospital, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article
|