|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0027651,
umls-concept:C0205179,
umls-concept:C0205217,
umls-concept:C0450442,
umls-concept:C0851346,
umls-concept:C0871261,
umls-concept:C1122629,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1801960,
umls-concept:C2349975,
umls-concept:C2911692
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2005-6-6
|
|
pubmed:abstractText |
ZD6126 is a vascular-targeting agent that induces selective effects on the morphology of proliferating and immature endothelial cells by disrupting the tubulin cytoskeleton. The efficacy of ZD6126 was investigated in large vs. small tumors in a variety of animal models.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0360-3016
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
62
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
846-53
|
|
pubmed:dateRevised |
2007-11-14
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|
pubmed:meshHeading |
pubmed-meshheading:15936569-Angiogenesis Inhibitors,
pubmed-meshheading:15936569-Animals,
pubmed-meshheading:15936569-Benzimidazoles,
pubmed-meshheading:15936569-Drug Screening Assays, Antitumor,
pubmed-meshheading:15936569-Fluorescent Dyes,
pubmed-meshheading:15936569-Humans,
pubmed-meshheading:15936569-Mice,
pubmed-meshheading:15936569-Mice, Inbred C3H,
pubmed-meshheading:15936569-Mice, Nude,
pubmed-meshheading:15936569-Necrosis,
pubmed-meshheading:15936569-Neoplasms,
pubmed-meshheading:15936569-Neovascularization, Pathologic,
pubmed-meshheading:15936569-Organophosphorus Compounds,
pubmed-meshheading:15936569-Sarcoma,
pubmed-meshheading:15936569-Transplantation, Heterologous
|
|
pubmed:year |
2005
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|
pubmed:articleTitle |
The vascular disrupting agent ZD6126 shows increased antitumor efficacy and enhanced radiation response in large, advanced tumors.
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|
pubmed:affiliation |
Department of Radiation Oncology, University of Florida Shands Cancer Center, Gainesville, FL 32610, USA. siemadw@ufl.edu
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
|
