Source:http://linkedlifedata.com/resource/pubmed/id/15936464
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2005-6-6
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pubmed:abstractText |
The presence of apolipoprotein (Apo) e4 allele is reported to be associated with the increased risk of coronary artery disease (CAD), as well as the impairment of endothelium-dependent arterial dilation in type 2 diabetes mellitus. Therefore, we hypothesized that Apo e4 allele increases the death risk from coronary artery disease in type 2 diabetes with ischaemia electrocardiographic change. From January 1993 to December 1999, 46 type 2 diabetic patients with e4/4 or e4/3, 96 with e3/3 and 45 with e2/2 or e3/2 genotypes were recruited. All subjects were unrelated elderly type 2 diabetic patients with ischaemia electrocardiographic change, aged 60-87 years, and their cardiac function were all the class I stage at their time of enrollment. A follow-up study of 3-10 years was undergone. The results are as follows: At baseline, serum total cholesterol and low-density lipoprotein (LDL) cholesterol concentrations were higher in subjects with e4/3 or e4/4 than in subjects with e2/2 or e3/2 (p<0.05). Lipoprotein(a) concentration was lower in subjects with e2/2 or e3/2 than in subjects with e3/3 and e4/3 or e4/4 (p < 0.05). During the 3-10 years follow-up period, a total of 55 patients who died from CAD were recorded in this sample. Compared with patients with e3/3 (p = 0.024) and patients with e2/2 or e2/3 genotypes (p = 0.002), the mortality rate of CAD in patients with e4/3 or e4/4 genotypes was the highest (47.8%). Stepwise discriminant analysis revealed that in the diabetic population studied Apo e4 allele was independently and significantly associated with CAD death (B = 0.65). However, the strength of the association decreased (B = 0.44) when total cholesterol, LDL-cholesterol and lipoprotein(a) were included in the model. Therefore, we concluded that Apo e4 allele increases the risk of CAD death in elderly type 2 diabetes mellitus with ischaemia electrocardiographic change.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0168-8227
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
223-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15936464-Aged,
pubmed-meshheading:15936464-Aged, 80 and over,
pubmed-meshheading:15936464-Alleles,
pubmed-meshheading:15936464-Apolipoprotein E4,
pubmed-meshheading:15936464-Apolipoproteins E,
pubmed-meshheading:15936464-Coronary Artery Disease,
pubmed-meshheading:15936464-Diabetes Mellitus, Type 2,
pubmed-meshheading:15936464-Diabetic Angiopathies,
pubmed-meshheading:15936464-Electrocardiography,
pubmed-meshheading:15936464-Female,
pubmed-meshheading:15936464-Genetic Predisposition to Disease,
pubmed-meshheading:15936464-Humans,
pubmed-meshheading:15936464-Male,
pubmed-meshheading:15936464-Middle Aged,
pubmed-meshheading:15936464-Myocardial Ischemia,
pubmed-meshheading:15936464-Risk
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pubmed:year |
2005
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pubmed:articleTitle |
Apolipoprotein e4 allele and the risk of CAD death in type 2 diabetes mellitus with ischaemia electrocardiographic change.
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pubmed:affiliation |
Department of Endocrinology, Wuhan General Hospital of Guangzhou Command of PLA, Wuhan 430070, PR China. guangda64@163.net
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pubmed:publicationType |
Journal Article
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