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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-6-6
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pubmed:abstractText |
Much of the patterning of early C. elegans embryos involves a series of Notch interactions that occur in rapid succession and have distinct outcomes; however, none of the targets for these interactions have been identified. We show that the REF-1 family of bHLH transcription factors is a major target of Notch signaling in all these interactions and that most examples of Notch-mediated transcriptional repression can be attributed to REF-1 activities. The REF-1 family is expressed and has similar functions in both Notch-dependent and Notch-independent pathways, and this dual mode of deployment is used repeatedly to pattern the embryo. REF-1 proteins are unusual in that they contain two different bHLH domains and lack the distinguishing characteristics of Hairy/Enhancer of Split (HES) bHLH proteins that are Notch targets in other systems. Our results show that the highly divergent REF-1 proteins are nonetheless HES-like bHLH effectors of Notch signaling.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Double-Stranded,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/notch protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/ref-1 protein, C elegans
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1534-5807
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
867-79
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pubmed:dateRevised |
2006-11-28
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pubmed:meshHeading |
pubmed-meshheading:15935776-Age Factors,
pubmed-meshheading:15935776-Animals,
pubmed-meshheading:15935776-Animals, Genetically Modified,
pubmed-meshheading:15935776-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:15935776-Caenorhabditis elegans,
pubmed-meshheading:15935776-Caenorhabditis elegans Proteins,
pubmed-meshheading:15935776-DNA-Binding Proteins,
pubmed-meshheading:15935776-Drosophila,
pubmed-meshheading:15935776-Drosophila Proteins,
pubmed-meshheading:15935776-Embryo, Nonmammalian,
pubmed-meshheading:15935776-Fluorescent Antibody Technique,
pubmed-meshheading:15935776-Gene Expression Regulation, Developmental,
pubmed-meshheading:15935776-Membrane Proteins,
pubmed-meshheading:15935776-Models, Biological,
pubmed-meshheading:15935776-Molecular Sequence Data,
pubmed-meshheading:15935776-Morphogenesis,
pubmed-meshheading:15935776-Mutagenesis,
pubmed-meshheading:15935776-RNA, Double-Stranded,
pubmed-meshheading:15935776-Receptors, Notch,
pubmed-meshheading:15935776-Sequence Alignment,
pubmed-meshheading:15935776-Signal Transduction,
pubmed-meshheading:15935776-Transcription Factors
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pubmed:year |
2005
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pubmed:articleTitle |
The REF-1 family of bHLH transcription factors pattern C. elegans embryos through Notch-dependent and Notch-independent pathways.
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pubmed:affiliation |
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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