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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-6-6
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pubmed:abstractText |
Beta-catenin-dependent or canonical Wnt signals are fundamental in animal development and tumor progression. Using Xenopus laevis, we report that the BTB/POZ zinc finger family member Kaiso directly represses canonical Wnt gene targets (Siamois, c-Fos, Cyclin-D1, and c-Myc) in conjunction with TCF/LEF (TCF). Analogous to beta-catenin relief of TCF repressive activity, we show that p120-catenin relieves Kaiso-mediated repression of Siamois. Furthermore, Kaiso and TCF coassociate, and combined Kaiso and TCF derepression results in pronounced Siamois expression and increased beta-catenin coprecipitation with the Siamois promoter. The functional interdependency is underlined by Kaiso suppression of beta-catenin-induced axis duplication and by TCF-3 rescue of Kaiso depletion phenotypes. These studies point to convergence of parallel p120-catenin/Kaiso and beta-catenin/TCF signaling pathways to regulate gene expression in vertebrate development and possibly carcinogenesis.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/XKaiso protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Xnr3 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/beta-catenin protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/siamois protein, Xenopus
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1534-5807
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pubmed:author |
pubmed-author:BartonMichelle CMC,
pubmed-author:ChoKyucheolK,
pubmed-author:DerooTomT,
pubmed-author:DickR ARA,
pubmed-author:JiHongH,
pubmed-author:KimSi WanSW,
pubmed-author:McCreaPierre DPD,
pubmed-author:MoonRandall TRT,
pubmed-author:NguyenThi TTT,
pubmed-author:ParkJae-IlJI,
pubmed-author:VleminckxKrisK
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
843-54
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pubmed:dateRevised |
2011-3-31
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pubmed:meshHeading |
pubmed-meshheading:15935774-Animals,
pubmed-meshheading:15935774-Blotting, Western,
pubmed-meshheading:15935774-Body Patterning,
pubmed-meshheading:15935774-Chromatin Immunoprecipitation,
pubmed-meshheading:15935774-Cloning, Molecular,
pubmed-meshheading:15935774-Cytoskeletal Proteins,
pubmed-meshheading:15935774-Dose-Response Relationship, Drug,
pubmed-meshheading:15935774-Drug Interactions,
pubmed-meshheading:15935774-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:15935774-Fluorescent Antibody Technique,
pubmed-meshheading:15935774-Gene Expression Regulation, Developmental,
pubmed-meshheading:15935774-Homeodomain Proteins,
pubmed-meshheading:15935774-Humans,
pubmed-meshheading:15935774-Immunoprecipitation,
pubmed-meshheading:15935774-In Situ Hybridization,
pubmed-meshheading:15935774-Microinjections,
pubmed-meshheading:15935774-Mutation,
pubmed-meshheading:15935774-Oligodeoxyribonucleotides, Antisense,
pubmed-meshheading:15935774-RNA, Messenger,
pubmed-meshheading:15935774-Repressor Proteins,
pubmed-meshheading:15935774-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15935774-Signal Transduction,
pubmed-meshheading:15935774-Trans-Activators,
pubmed-meshheading:15935774-Transcription, Genetic,
pubmed-meshheading:15935774-Transforming Growth Factor beta,
pubmed-meshheading:15935774-Xenopus Proteins,
pubmed-meshheading:15935774-Xenopus laevis,
pubmed-meshheading:15935774-beta Catenin
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pubmed:year |
2005
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pubmed:articleTitle |
Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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