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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-6-6
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pubmed:abstractText |
Antidepressant drugs have a clinical latency that correlates with the development of neuroadaptive changes, including down-regulation of beta-adrenergic receptors in different brain regions. The identification of drugs that shorten this latency will have a great impact on the treatment of major depressive disorders. We report that the time required for the antidepressant imipramine to reduce the expression of beta-adrenergic receptors in the hippocampus is reduced by a co-administration with centrally active ligands of type 2/3 metabotropic glutamate (mGlu2/3) receptors. Daily treatment of mice with imipramine alone (10 mg/kg, i.p.) reduced the expression of beta-adrenergic receptors in the hippocampus after 21 days, but not at shorter times, as assessed by western blot analysis of beta1-adrenergic receptors and by the amount of specifically bound [3H]CGP-12177, a selective beta-adrenergic receptor ligand. Down-regulation of beta-adrenergic receptors occurred at shorter times (i.e. after 14 days) when imipramine was combined with low doses (0.5 mg/kg, i.p.) of the selective mGlu2/3 receptor agonist LY379268, or with the preferential mGlu2/3 receptor antagonist LY341495 (1 mg/kg, i.p.). Higher doses of LY379268 (2 mg/kg, i.p.) were inactive. This intriguing finding suggests that neuroadaptation to imipramine--at least as assessed by changes in the expression of beta1-adrenergic receptors--is influenced by drugs that interact with mGlu2/3 receptors and stimulates further research aimed at establishing whether any of these drugs can shorten the clinical latency of classical antidepressants.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents, Tricyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds, Heterocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Imipramine,
http://linkedlifedata.com/resource/pubmed/chemical/LY 341495,
http://linkedlifedata.com/resource/pubmed/chemical/LY 379268,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthenes,
http://linkedlifedata.com/resource/pubmed/chemical/metabotropic glutamate receptor 2,
http://linkedlifedata.com/resource/pubmed/chemical/metabotropic glutamate receptor 3
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-3042
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pubmed:author |
pubmed-author:BattagliaGG,
pubmed-author:CanudasA MAM,
pubmed-author:Del BiancoPP,
pubmed-author:MatriscianoFF,
pubmed-author:MelchiorriDD,
pubmed-author:MolinariAA,
pubmed-author:NgombaR TRT,
pubmed-author:NicolettiFF,
pubmed-author:PanaccioneII,
pubmed-author:RiozziBB,
pubmed-author:ScaccianoceSS,
pubmed-author:TatarelliRR
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pubmed:issnType |
Print
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1345-52
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15934953-Adaptation, Physiological,
pubmed-meshheading:15934953-Amino Acids,
pubmed-meshheading:15934953-Animals,
pubmed-meshheading:15934953-Antidepressive Agents, Tricyclic,
pubmed-meshheading:15934953-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:15934953-Down-Regulation,
pubmed-meshheading:15934953-Excitatory Amino Acid Antagonists,
pubmed-meshheading:15934953-Hippocampus,
pubmed-meshheading:15934953-Imipramine,
pubmed-meshheading:15934953-Ligands,
pubmed-meshheading:15934953-Male,
pubmed-meshheading:15934953-Mice,
pubmed-meshheading:15934953-Mice, Inbred Strains,
pubmed-meshheading:15934953-Nervous System Physiological Phenomena,
pubmed-meshheading:15934953-Reaction Time,
pubmed-meshheading:15934953-Receptors, Adrenergic, beta,
pubmed-meshheading:15934953-Receptors, Metabotropic Glutamate,
pubmed-meshheading:15934953-Xanthenes
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pubmed:year |
2005
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pubmed:articleTitle |
Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of beta-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands.
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pubmed:affiliation |
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy.
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pubmed:publicationType |
Journal Article
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