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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2005-6-2
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pubmed:abstractText |
We investigated insertion (Ins)/deletion(Del) polymorphism in alpha-2-macroglobulin (A2M), G/C variant in the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) and apolipoprotein E (APOE) gene epsilon2/epsilon3/epsilon4 polymorphism in 387 Chinese Han ethnic patients with Alzheimer's disease and healthy study participants. After stratification for APOEepsilon4 status, only the BACE1-G allele with APOEepsilon4 was significantly associated with Alzheimer's disease. Through meta-analysis of the Del or G allele by pooling Asian studies, only BACE1-G allele appeared to increase risk of developing Alzheimer's disease. Through combination-analysis of the data about the A2M-I/D and the A2M-Ile1000Val variants, the A2M gene was suggested to be associated with Alzheimer's disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0959-4965
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1023-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15931081-Adult,
pubmed-meshheading:15931081-Aged,
pubmed-meshheading:15931081-Aged, 80 and over,
pubmed-meshheading:15931081-Alzheimer Disease,
pubmed-meshheading:15931081-Amyloid Precursor Protein Secretases,
pubmed-meshheading:15931081-Apolipoproteins E,
pubmed-meshheading:15931081-Asian Continental Ancestry Group,
pubmed-meshheading:15931081-Aspartic Acid Endopeptidases,
pubmed-meshheading:15931081-Chi-Square Distribution,
pubmed-meshheading:15931081-China,
pubmed-meshheading:15931081-DNA Mutational Analysis,
pubmed-meshheading:15931081-Endopeptidases,
pubmed-meshheading:15931081-Female,
pubmed-meshheading:15931081-Gene Frequency,
pubmed-meshheading:15931081-Genotype,
pubmed-meshheading:15931081-Humans,
pubmed-meshheading:15931081-Isoleucine,
pubmed-meshheading:15931081-Male,
pubmed-meshheading:15931081-Meta-Analysis as Topic,
pubmed-meshheading:15931081-Middle Aged,
pubmed-meshheading:15931081-Polymorphism, Genetic,
pubmed-meshheading:15931081-Valine,
pubmed-meshheading:15931081-alpha-Macroglobulins
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pubmed:year |
2005
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pubmed:articleTitle |
Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer's disease patients.
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pubmed:affiliation |
State Key Lab of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
