Linked Life Data

15931071

Source:http://linkedlifedata.com/resource/pubmed/id/15931071

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2005-6-2
pubmed:abstractText
Retinitis pigmentosa is one of the main causes of blindness throughout the world and its pathogenesis remains unclear. In this study, patch-clamp recording was performed from ganglion cells in retinal dystrophic Royal College of Surgeons rats and normal rats during development. The three discharge patterns of action potential in ganglion cells of Royal College of Surgeons rats were single, transient, and sustained firing. The main discharge pattern was single firing in P1-2W, then transient and sustained firing. However, during later stages of retinal degeneration, action potential was reduced in amplitude and frequency, and was even lost in Royal College of Surgeons rats. These findings differed dramatically from those of rats without retinal degeneration, suggesting there are functional ganglion cells in Royal College of Surgeons rats early, but lose part function during retinal degeneration, even though morphological differences are not apparent. Understanding the changes of electrophysiological characteristics during retinal degeneration in detail may help explore the optimal time course for treating retinitis pigmentosa.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
971-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Electrophysiological changes of retinal ganglion cells in Royal College of Surgeons rats during retinal degeneration.
pubmed:affiliation
Southwest Eye Hospital, Southwest Hospital, Chongqing 400038, China 2NEI, NIH, Bethesda, MD 20892-4066, USA.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't