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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2005-6-2
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pubmed:abstractText |
In this study, we examined changes in expression of calcium/calmodulin-dependent protein kinase IV (CaMKIV) in the mouse brain following chronic morphine treatment. Double immunohistochemical staining showed strong colocalization of CaMKIV with mu-opioid receptors. Chronic treatment with morphine produced an increase in expression of CaMKIV and phosphorylated cAMP response element-binding protein (pCREB) in the CA3 region of the hippocampus, whereas a decrease in CaMKIV and pCREB expression was observed in the caudate putamen. Interestingly, chronic morphine induced a decrease in protein expression of CaMKIV in the basolateral amygdale and the primary somatosensory cortex without any concomitant changes in pCREB. These findings suggest that CaMKIV-dependent signaling may play a role in chronic morphine-induced neuroplasticity in a brain region-specific manner.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Camk1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Camk4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP Response...,
http://linkedlifedata.com/resource/pubmed/chemical/DAPI,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotics,
http://linkedlifedata.com/resource/pubmed/chemical/Pnck protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
879-82
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15931054-Animals,
pubmed-meshheading:15931054-Brain,
pubmed-meshheading:15931054-Calcium-Calmodulin-Dependent Protein Kinase Type 1,
pubmed-meshheading:15931054-Calcium-Calmodulin-Dependent Protein Kinase Type 4,
pubmed-meshheading:15931054-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:15931054-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:15931054-Gene Expression Regulation,
pubmed-meshheading:15931054-Immunohistochemistry,
pubmed-meshheading:15931054-Indoles,
pubmed-meshheading:15931054-Male,
pubmed-meshheading:15931054-Mice,
pubmed-meshheading:15931054-Morphine,
pubmed-meshheading:15931054-Narcotics,
pubmed-meshheading:15931054-Phosphorylation,
pubmed-meshheading:15931054-Receptors, Opioid, mu
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pubmed:year |
2005
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pubmed:articleTitle |
Region-specific changes of calcium/calmodulin-dependent protein kinase IV in the mouse brain following chronic morphine treatment.
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pubmed:affiliation |
Department of Psychology and Centre for Research on Pain, McGill University, 1205 Dr Penfield Avenue, Montréal, Canada, Que. H3A 1B1.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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