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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2005-6-2
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pubmed:abstractText |
Treatment of hepatocellular carcinoma raised on cirrhotic liver represents a major endeavor because surgery and chemotherapeutic management fail to improve the clinical course of the disease. Chemoprevention could represent an important means to inhibit the process of hepatocarcinogenesis. Farnesyltransferase inhibitors are a class of drugs blocking the growth of tumor cells with minimal toxicity towards normal cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ABT-100,
http://linkedlifedata.com/resource/pubmed/chemical/AKT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Akt1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Alkyl and Aryl Transferases,
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Diethylnitrosamine,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Farnesyltranstransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/rap1 GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4266-74
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15930366-Alkyl and Aryl Transferases,
pubmed-meshheading:15930366-Animals,
pubmed-meshheading:15930366-Carcinoma, Hepatocellular,
pubmed-meshheading:15930366-Carrier Proteins,
pubmed-meshheading:15930366-Cell Line, Tumor,
pubmed-meshheading:15930366-Cell Movement,
pubmed-meshheading:15930366-Cell Proliferation,
pubmed-meshheading:15930366-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:15930366-Diethylnitrosamine,
pubmed-meshheading:15930366-Disease Models, Animal,
pubmed-meshheading:15930366-Enzyme Activation,
pubmed-meshheading:15930366-Enzyme Inhibitors,
pubmed-meshheading:15930366-Farnesyltranstransferase,
pubmed-meshheading:15930366-Female,
pubmed-meshheading:15930366-Humans,
pubmed-meshheading:15930366-Imidazoles,
pubmed-meshheading:15930366-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15930366-Liver Neoplasms,
pubmed-meshheading:15930366-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:15930366-Phosphorylation,
pubmed-meshheading:15930366-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15930366-Proto-Oncogene Proteins,
pubmed-meshheading:15930366-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:15930366-Rats,
pubmed-meshheading:15930366-Rats, Wistar,
pubmed-meshheading:15930366-rap1 GTP-Binding Proteins,
pubmed-meshheading:15930366-ras Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
Farnesyltransferase inhibitor, ABT-100, is a potent liver cancer chemopreventive agent.
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pubmed:affiliation |
Dipartimento di Medicina Interna, Università di Firenze, Florence, Italy. v.carloni@dmi.unifi.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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