Linked Life Data

15929864

Source:http://linkedlifedata.com/resource/pubmed/id/15929864

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-6-2
pubmed:abstractText
Aggregation of the beta-cell product islet amyloid polypeptide (IAPP) is believed to be an important event in the development of the beta-cell lesion in type 2 diabetes. Preamyloidotic oligomeric IAPP assemblies exert toxic effects on beta cells that die, leading to reduced beta-cell mass. Normal human islets, when isolated and cultured in vitro or transplanted into nude mice, also develop amyloid deposits, which are associated with increased beta-cell death and reduced beta-cell mass. The possible role of IAPP aggregation and amyloid formation in loss of islet transplant function should be taken into consideration and studied further.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1534-4827
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
184-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Is aggregated IAPP a cause of beta-cell failure in transplanted human pancreatic islets?
pubmed:affiliation
Linköping University, Department of Biomedicine and Surgery, Cell Biology, 12, University Hospital, Linköping SE 581 85, Sweden. Per.Westermark@genpat.uu.se
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't