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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
21
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pubmed:dateCreated |
2005-6-1
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|
pubmed:abstractText |
Progression of pulmonary hypertension (PH) is associated with increased lung expression of the serotonin transporter (5-HTT), which leads to hyperplasia of the pulmonary artery smooth muscle cells (PA-SMCs). Given the postulated causal relation between 5-HTT overexpression and PH, we herein investigated whether the highly selective 5-HTT inhibitor fluoxetine prevented and/or reversed PH induced by monocrotaline (MCT) in rats. Selective 5-HT(1B/1D), 5-HT(2A), and 5-HT(2B) receptor antagonists were used for comparative testing.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1524-4539
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pubmed:author |
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|
pubmed:issnType |
Electronic
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pubmed:day |
31
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2812-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15927991-Animals,
pubmed-meshheading:15927991-Cell Proliferation,
pubmed-meshheading:15927991-Fluoxetine,
pubmed-meshheading:15927991-Hypertension, Pulmonary,
pubmed-meshheading:15927991-Lung,
pubmed-meshheading:15927991-Monocrotaline,
pubmed-meshheading:15927991-Muscle, Smooth, Vascular,
pubmed-meshheading:15927991-Rats,
pubmed-meshheading:15927991-Serotonin 5-HT1 Receptor Antagonists,
pubmed-meshheading:15927991-Serotonin 5-HT2 Receptor Antagonists,
pubmed-meshheading:15927991-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:15927991-Serotonin Uptake Inhibitors,
pubmed-meshheading:15927991-Up-Regulation
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pubmed:year |
2005
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|
pubmed:articleTitle |
Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats.
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pubmed:affiliation |
Département de Physiologie, INSERM U492, AP-HP, CHU Henri Mondor, Créteil, France.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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