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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2005-6-7
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pubmed:abstractText |
Human pulmonary arterial hypertension (PAH) is characterized by proliferation of vascular smooth muscle and, in its more severe form, by the development of occlusive neointimal lesions. However, few animal models of pulmonary neointimal proliferation exist, thereby limiting a complete understanding of the pathobiology of PAH. Recent studies of the endothelin (ET) system demonstrate that deficiency of the ET(B) receptor predisposes adult rats to acute and chronic hypoxic PAH, yet these animals fail to develop neointimal lesions. Herein, we determined and thereafter showed that exposure of ET(B) receptor-deficient rats to the endothelial toxin monocrotaline (MCT) leads to the development of neointimal lesions that share hallmarks of human PAH.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-10835689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-11076971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-11156958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-11590837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-11590839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-11673836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-11713135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-11907289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-12370225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-12709727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-12919946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-12970226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-14630619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-14695338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-15243299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-15359489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-15516365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-1648907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-1850424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-2115743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-709766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-7491987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-7508683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-8147891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-8182146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-8570650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-8755654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-9094991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-9314546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-9327735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-9605569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-9731029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-9739043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15927975-9927344
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
7
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2988-96
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pubmed:dateRevised |
2011-6-2
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pubmed:meshHeading |
pubmed-meshheading:15927975-Animals,
pubmed-meshheading:15927975-Animals, Genetically Modified,
pubmed-meshheading:15927975-Arterial Occlusive Diseases,
pubmed-meshheading:15927975-Cell Proliferation,
pubmed-meshheading:15927975-Disease Models, Animal,
pubmed-meshheading:15927975-Hypertension,
pubmed-meshheading:15927975-Hypertrophy, Right Ventricular,
pubmed-meshheading:15927975-Monocrotaline,
pubmed-meshheading:15927975-Muscle, Smooth, Vascular,
pubmed-meshheading:15927975-Pulmonary Artery,
pubmed-meshheading:15927975-Rats,
pubmed-meshheading:15927975-Receptor, Endothelin B,
pubmed-meshheading:15927975-Tunica Intima
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pubmed:year |
2005
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pubmed:articleTitle |
Development of occlusive neointimal lesions in distal pulmonary arteries of endothelin B receptor-deficient rats: a new model of severe pulmonary arterial hypertension.
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pubmed:affiliation |
Section of Pediatric Cardiology, University of Colorado School of Medicine and Children's Hospital, Denver 80218, USA. ivy.dunbar@tchden.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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