| pubmed-article:15927954 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15927954 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15927954 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:15927954 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15927954 | lifeskim:mentions | umls-concept:C0034830 | lld:lifeskim |
| pubmed-article:15927954 | lifeskim:mentions | umls-concept:C0599896 | lld:lifeskim |
| pubmed-article:15927954 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
| pubmed-article:15927954 | pubmed:issue | 29 | lld:pubmed |
| pubmed-article:15927954 | pubmed:dateCreated | 2005-7-19 | lld:pubmed |
| pubmed-article:15927954 | pubmed:abstractText | The ric-3 gene is required for maturation of nicotinic acetylcholine receptors in Caenorhabditis elegans. The human homolog of RIC-3, hRIC-3, enhances expression of alpha7 nicotinic receptors in Xenopus laevis oocytes, whereas it totally abolishes expression of alpha4beta2 nicotinic and 5-HT3 serotonergic receptors. Both the N-terminal region of hRIC-3, which contains two transmembrane segments, and the C-terminal region are needed for these differential effects. hRIC-3 inhibits receptor expression by hindering export of mature receptors to the cell membrane. By using chimeric proteins made of alpha7 and 5-HT3 receptors, we have shown that the presence of an extracellular isoleucine close to the first transmembrane receptor fragment is responsible for the transport arrest induced by hRIC-3. Enhancement of alpha7 receptor expression occurs, at least, at two levels: by increasing the number of mature receptors and facilitating its transport to the membrane. Certain amino acids of a putative amphipathic helix present at the large cytoplasmic region of the alpha7 subunit are required for these actions. Therefore, hRIC-3 can act as a specific regulator of receptor expression at different levels. | lld:pubmed |
| pubmed-article:15927954 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15927954 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15927954 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15927954 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15927954 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15927954 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15927954 | pubmed:author | pubmed-author:CriadoManuelM | lld:pubmed |
| pubmed-article:15927954 | pubmed:author | pubmed-author:GutiérrezLuis... | lld:pubmed |
| pubmed-article:15927954 | pubmed:author | pubmed-author:SalaFrancisco... | lld:pubmed |
| pubmed-article:15927954 | pubmed:author | pubmed-author:MuletJoséJ | lld:pubmed |
| pubmed-article:15927954 | pubmed:author | pubmed-author:SalaSalvadorS | lld:pubmed |
| pubmed-article:15927954 | pubmed:author | pubmed-author:CastilloMarM | lld:pubmed |
| pubmed-article:15927954 | pubmed:author | pubmed-author:OrtizJosé AJA | lld:pubmed |
| pubmed-article:15927954 | pubmed:author | pubmed-author:GerberSusanaS | lld:pubmed |
| pubmed-article:15927954 | pubmed:author | pubmed-author:CastelánFranc... | lld:pubmed |
| pubmed-article:15927954 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15927954 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:15927954 | pubmed:volume | 280 | lld:pubmed |
| pubmed-article:15927954 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15927954 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15927954 | pubmed:pagination | 27062-8 | lld:pubmed |
| pubmed-article:15927954 | pubmed:dateRevised | 2010-6-4 | lld:pubmed |
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| pubmed-article:15927954 | pubmed:meshHeading | pubmed-meshheading:15927954... | lld:pubmed |
| pubmed-article:15927954 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15927954 | pubmed:articleTitle | Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors. | lld:pubmed |
| pubmed-article:15927954 | pubmed:affiliation | Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, Apartado 18, 03550 Sant Joan d'Alacant, Alicante, Spain. | lld:pubmed |
| pubmed-article:15927954 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15927954 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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