Source:http://linkedlifedata.com/resource/pubmed/id/15925543
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2005-12-19
|
| pubmed:abstractText |
Tuberculosis (TB) has different clinical presentations. Pulmonary TB affects only the lungs and exhibits variable anti-mycobacterial immune responses. Pleural TB is a localized disease with a strong immune response. Miliary TB is a disseminated form with poor immune response. Cytokines play a pivotal role in anti-mycobacterial response and may determine the type of TB. Thus, gene polymorphisms associated with cytokine production may be associated with clinical presentations of TB. In this study, 54 tuberculin-negative healthy controls, 81 tuberculin-positive healthy controls, 140 patients with pulmonary TB, 30 with pleural TB and 20 with miliary TB were studied. Single nucleotide polymorphisms were typed for tumour necrosis factor-alpha, interferon-gamma (IFN-gamma), transforming growth factor-beta1, interleukin-10 (IL-10) and interleukin-6 by sequence-specific primer polymerase chain reaction (SSP-PCR). Allelic, genotypic and haplotypic associations with clinical forms of TB were evaluated. IL-10 -1082 A/A genotype and IFNgamma+874 T allele were associated with pleural TB. Seventy-five extended genotypes were found; two differed between patients and controls, and two between groups of patients. Results suggest that IL-10 low-producer polymorphism and IFN-gamma high-producer polymorphism are associated with pleural TB.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
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| pubmed:issn |
1472-9792
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
86
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
11-9
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| pubmed:dateRevised |
2009-4-22
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| pubmed:meshHeading |
pubmed-meshheading:15925543-Adolescent,
pubmed-meshheading:15925543-Adult,
pubmed-meshheading:15925543-Aged,
pubmed-meshheading:15925543-Case-Control Studies,
pubmed-meshheading:15925543-Colombia,
pubmed-meshheading:15925543-Cytokines,
pubmed-meshheading:15925543-Female,
pubmed-meshheading:15925543-Humans,
pubmed-meshheading:15925543-Interferon-gamma,
pubmed-meshheading:15925543-Interleukin-10,
pubmed-meshheading:15925543-Interleukin-6,
pubmed-meshheading:15925543-Male,
pubmed-meshheading:15925543-Middle Aged,
pubmed-meshheading:15925543-Polymorphism, Genetic,
pubmed-meshheading:15925543-Transforming Growth Factor beta,
pubmed-meshheading:15925543-Tuberculosis, Miliary,
pubmed-meshheading:15925543-Tuberculosis, Pleural,
pubmed-meshheading:15925543-Tuberculosis, Pulmonary,
pubmed-meshheading:15925543-Tumor Necrosis Factor-alpha
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Cytokine gene polymorphisms in Colombian patients with different clinical presentations of tuberculosis.
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| pubmed:affiliation |
Grupo de Inmunología Celular e Inmunogenética, Sede de Investigación Universitaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|