| pubmed-article:1592435 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1592435 | lifeskim:mentions | umls-concept:C0036945 | lld:lifeskim |
| pubmed-article:1592435 | lifeskim:mentions | umls-concept:C0031272 | lld:lifeskim |
| pubmed-article:1592435 | lifeskim:mentions | umls-concept:C0018120 | lld:lifeskim |
| pubmed-article:1592435 | lifeskim:mentions | umls-concept:C0221971 | lld:lifeskim |
| pubmed-article:1592435 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:1592435 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:1592435 | lifeskim:mentions | umls-concept:C0020885 | lld:lifeskim |
| pubmed-article:1592435 | lifeskim:mentions | umls-concept:C1571705 | lld:lifeskim |
| pubmed-article:1592435 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:1592435 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:1592435 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:1592435 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:1592435 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1592435 | pubmed:dateCreated | 1992-7-2 | lld:pubmed |
| pubmed-article:1592435 | pubmed:abstractText | We developed a method to isolate and culture cells from the lymphoid follicles of the ileal Peyer's (PP) patch of young sheep (6-12 weeks). These cells were 98% sIgM+ B cells and 1% T cells. Cultured follicular cells were used to investigate B-cell proliferation and differentiation. Less than 50% of B cells were viable after 24 hr of culture and this decrease in B-cell viability also occurred following co-stimulation with pokeweed mitogen (PWM) and recombinant bovine interleukin-1 (rBoIL-1) or rBoIL-2. In contrast, co-stimulation with PWM and either rBoIL-1 or rBoIL-2 induced a marked proliferative response that was maximal on Day 4 of culture. Cytokine-induced proliferation of the B cells required PWM co-stimulation and proliferation induced by rBoIL-1 and rBoIL-2 was neither additive or synergistic. This suggests that PWM bound a molecule or molecules that signalled responsiveness to both rBoIL-1 and rBoIL-2. Culture of follicular cells with PWM and both rBoIL-1 and rBoIL-2 also resulted in B-cell differentiation. This differentiation was associated with decreased proliferation, an increased number of viable B cells, and increased expression of both surface IgM and non-Ig membrane molecules. Thus, co-stimulation of ileal PP follicular cells with PWM and rBoIL-1 and rBoIL-2 resulted in both B-cell proliferation and differentiation. | lld:pubmed |
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| pubmed-article:1592435 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1592435 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1592435 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1592435 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1592435 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1592435 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:1592435 | pubmed:author | pubmed-author:DavisW CWC | lld:pubmed |
| pubmed-article:1592435 | pubmed:author | pubmed-author:ReynoldsJ DJD | lld:pubmed |
| pubmed-article:1592435 | pubmed:author | pubmed-author:GriebelP JPJ | lld:pubmed |
| pubmed-article:1592435 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1592435 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:1592435 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1592435 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1592435 | pubmed:pagination | 601-7 | lld:pubmed |
| pubmed-article:1592435 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1592435 | pubmed:meshHeading | pubmed-meshheading:1592435-... | lld:pubmed |
| pubmed-article:1592435 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1592435 | pubmed:articleTitle | An analysis of the growth and differentiation of B cells isolated from follicles of the ileal Peyer's patch of sheep. | lld:pubmed |
| pubmed-article:1592435 | pubmed:affiliation | Department of Medical Physiology, University of Calgary, Canada. | lld:pubmed |
| pubmed-article:1592435 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1592435 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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