| pubmed-article:1592434 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1592434 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1592434 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:1592434 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:1592434 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:1592434 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1592434 | pubmed:dateCreated | 1992-7-2 | lld:pubmed |
| pubmed-article:1592434 | pubmed:abstractText | B cells, distinct from those seen in myasthenia gravis, are present in normal human thymic medulla, concentrated around the Hassall's corpuscles. We have shown that they constitute 33 +/- 4.8% of the total cells in the thymic medulla. In tissue sections they were often seen to have rosettes of thymocytes around them, a relationship which was maintained when the cells were isolated from the thymus. Thymic B cells expressed cytoplasmic immunoglobulins IgD, IgM and IgG but only rarely IgA. Unlike murine thymic B cells, human thymic B cells were CD5-. Freshly isolated thymic B cells were activated cells, but they rapidly became quiescent and died in culture over a 10-day period unless stimulated with mitogens. Thymic B cells responded to polyclonal B-cell activators SAC and TPA and when stimulated, maintained their relationship with thymocytes. Electron microscopic studies showed that two morphologically different thymocyte populations associated with the B cells. The plasma membranes of larger thymocytes were juxtaposed to the B-cell membrane, but smaller thymocytes with darker cytoplasm were associated with the B cells via cytoplasmic strands. Studies in mice have suggested that B cells are involved in thymic negative selection. The close association between activated B cells and thymocytes observed in this study supports this hypothesis. | lld:pubmed |
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| pubmed-article:1592434 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1592434 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1592434 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1592434 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1592434 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1592434 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:1592434 | pubmed:author | pubmed-author:SpencerJJ | lld:pubmed |
| pubmed-article:1592434 | pubmed:author | pubmed-author:PapadakiLL | lld:pubmed |
| pubmed-article:1592434 | pubmed:author | pubmed-author:ChoyMM | lld:pubmed |
| pubmed-article:1592434 | pubmed:author | pubmed-author:IsaacsonP GPG | lld:pubmed |
| pubmed-article:1592434 | pubmed:author | pubmed-author:HussellTT | lld:pubmed |
| pubmed-article:1592434 | pubmed:author | pubmed-author:KingtonJ PJP | lld:pubmed |
| pubmed-article:1592434 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1592434 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:1592434 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1592434 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1592434 | pubmed:pagination | 596-600 | lld:pubmed |
| pubmed-article:1592434 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1592434 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1592434 | pubmed:articleTitle | Properties of human thymic B cells. | lld:pubmed |
| pubmed-article:1592434 | pubmed:affiliation | Dept. of Histopathology, UCMSM, University St, London, U.K. | lld:pubmed |
| pubmed-article:1592434 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1592434 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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