Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-7-2
pubmed:abstractText
B cells, distinct from those seen in myasthenia gravis, are present in normal human thymic medulla, concentrated around the Hassall's corpuscles. We have shown that they constitute 33 +/- 4.8% of the total cells in the thymic medulla. In tissue sections they were often seen to have rosettes of thymocytes around them, a relationship which was maintained when the cells were isolated from the thymus. Thymic B cells expressed cytoplasmic immunoglobulins IgD, IgM and IgG but only rarely IgA. Unlike murine thymic B cells, human thymic B cells were CD5-. Freshly isolated thymic B cells were activated cells, but they rapidly became quiescent and died in culture over a 10-day period unless stimulated with mitogens. Thymic B cells responded to polyclonal B-cell activators SAC and TPA and when stimulated, maintained their relationship with thymocytes. Electron microscopic studies showed that two morphologically different thymocyte populations associated with the B cells. The plasma membranes of larger thymocytes were juxtaposed to the B-cell membrane, but smaller thymocytes with darker cytoplasm were associated with the B cells via cytoplasmic strands. Studies in mice have suggested that B cells are involved in thymic negative selection. The close association between activated B cells and thymocytes observed in this study supports this hypothesis.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1592434-1683054, http://linkedlifedata.com/resource/pubmed/commentcorrection/1592434-1683905, http://linkedlifedata.com/resource/pubmed/commentcorrection/1592434-1694056, http://linkedlifedata.com/resource/pubmed/commentcorrection/1592434-1703924, http://linkedlifedata.com/resource/pubmed/commentcorrection/1592434-1900074, http://linkedlifedata.com/resource/pubmed/commentcorrection/1592434-2085487, http://linkedlifedata.com/resource/pubmed/commentcorrection/1592434-2156431, http://linkedlifedata.com/resource/pubmed/commentcorrection/1592434-2209688, http://linkedlifedata.com/resource/pubmed/commentcorrection/1592434-2447458, http://linkedlifedata.com/resource/pubmed/commentcorrection/1592434-2451873, http://linkedlifedata.com/resource/pubmed/commentcorrection/1592434-3157869, http://linkedlifedata.com/resource/pubmed/commentcorrection/1592434-3261779, http://linkedlifedata.com/resource/pubmed/commentcorrection/1592434-4549732, http://linkedlifedata.com/resource/pubmed/commentcorrection/1592434-6206131, http://linkedlifedata.com/resource/pubmed/commentcorrection/1592434-6422024, http://linkedlifedata.com/resource/pubmed/commentcorrection/1592434-6756733
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0019-2805
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
596-600
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Properties of human thymic B cells.
pubmed:affiliation
Dept. of Histopathology, UCMSM, University St, London, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't