A low proliferating fraction in solid tumors limits the effectiveness of cell-cycle-dependent chemotherapeutic agents. To understand the molecular basis of such resistance, we examined the expression of the cyclin-dependent kinases inhibitor p27, and relationship with drug resistance and P-gp expression in ovarian cancer multicellular spheroids.
Department of Obsterics and Gynecology, Tongji Hospital Affiliated to Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People Republic of China.
