15924242

Source:http://linkedlifedata.com/resource/pubmed/id/15924242

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0013216, umls-concept:C0169665, umls-concept:C0282501, umls-concept:C0683598, umls-concept:C1140680, umls-concept:C1280500
pubmed:issue	8
pubmed:dateCreated	2005-8-31
pubmed:abstractText	A low proliferating fraction in solid tumors limits the effectiveness of cell-cycle-dependent chemotherapeutic agents. To understand the molecular basis of such resistance, we examined the expression of the cyclin-dependent kinases inhibitor p27, and relationship with drug resistance and P-gp expression in ovarian cancer multicellular spheroids.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7902060
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor..., http://linkedlifedata.com/resource/pubmed/chemical/Cyclins, http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense, http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoprotein, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0171-5216
pubmed:author	pubmed-author:DeanA CAC, pubmed-author:GaoQinglaiQ, pubmed-author:HuKeqinK, pubmed-author:LiJingJ, pubmed-author:LuYunpinY, pubmed-author:TaoWenmingW, pubmed-author:WangShixuanS, pubmed-author:WengDanhuiD, pubmed-author:XingHuiH, pubmed-author:YangXiaokuiX
pubmed:issnType	Print
pubmed:volume	131
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	511-9
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:15924242-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:15924242-Blotting, Western, pubmed-meshheading:15924242-Cell Cycle, pubmed-meshheading:15924242-Cell Cycle Proteins, pubmed-meshheading:15924242-Cyclin-Dependent Kinase Inhibitor p27, pubmed-meshheading:15924242-Cyclins, pubmed-meshheading:15924242-Down-Regulation, pubmed-meshheading:15924242-Drug Resistance, Neoplasm, pubmed-meshheading:15924242-Female, pubmed-meshheading:15924242-Flow Cytometry, pubmed-meshheading:15924242-Humans, pubmed-meshheading:15924242-Microscopy, Confocal, pubmed-meshheading:15924242-Oligonucleotides, Antisense, pubmed-meshheading:15924242-Ovarian Neoplasms, pubmed-meshheading:15924242-P-Glycoprotein, pubmed-meshheading:15924242-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:15924242-Spheroids, Cellular, pubmed-meshheading:15924242-Tumor Cells, Cultured, pubmed-meshheading:15924242-Tumor Suppressor Proteins
pubmed:year	2005
pubmed:articleTitle	Effect of the cyclin-dependent kinases inhibitor p27 on resistance of ovarian cancer multicellular spheroids to anticancer chemotherapy.
pubmed:affiliation	Department of Obsterics and Gynecology, Tongji Hospital Affiliated to Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People Republic of China.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't