Linked Life Data

15923382

Source:http://linkedlifedata.com/resource/pubmed/id/15923382

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-7-18
pubmed:abstractText
In this issue of Molecular Pharmacology, Oliveras-Reyes et al. (p. 356) describe the agonist-stimulated formation of a caveolin-dependent signalplex that includes both the angiotensin AT(1) receptor and the epidermal growth factor receptor, and probably also a number of other signal transduction intermediates. The signalplex is thought to facilitate the action of protein kinases that mediate angiotensin II-induced transactivation of the epidermal growth factor receptor and activation of extracellular signal-regulated kinase, and epidermal growth factor-induced inositol phosphate accumulation and phosphorylation/desensitization of the AT(1) receptor. This work contributes to an emerging view of the complexity and nonlinearity of signaling via G protein-coupled receptors and receptor tyrosine kinases, and of the importance of membrane compartmentalization to signal transduction.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0026-895X
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
275-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Double feature at the signalplex.
pubmed:affiliation
VA Medical Center (R&D-30), 3710 SW US Veterans Hospital Rd, Portland, OR 97239-2999, USA. nevek@ohsu.edu
pubmed:publicationType
Journal Article, Comment, Review