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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-5-30
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pubmed:abstractText |
We analyzed survivin as a marker of cervical intraepithelial neoplasia (CIN) and high-risk human papillomavirus (HR-HPV) and a predictor of HPV clearance and disease outcome in cervical cancer in 302 samples (squamous cell carcinomas [SCCs], 150; CIN lesions, 152) by immunohistochemical staining with survivin antibody and HPV testing using polymerase chain reaction. HR-HPV types were associated closely with CIN and SCC. There was a significant linear relationship between grade and intensity of survivin expression (P = .0001). Survivin overexpression also was associated strongly with HR-HPV type (P = .0001). Multivariate regression analysis revealed survivin and p16(INK4a) as equally strong independent predictors of HR-HPV. Deregulated survivin expression did not predict clearance or persistence of HR-HPV after treatment of CIN or survival in cervical cancer in univariate (P = .417) or multivariate analysis. After adjustment for HR-HPV, stage, age, and tumor grade in the Cox regression model, only stage (P = .0001) and age (P = .0001) remained independent prognostic predictors. Survivin seems to be an early marker of cervical carcinogenesis. Up-regulated survivin expression was an independent predictor of HR-HPV in cervical lesions, most plausibly explained by its normal transcriptional repression by wild-type p53 being eliminated by HR-HPV E6 oncoprotein.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0002-9173
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pubmed:author |
pubmed-author:AccardiLuisaL,
pubmed-author:BenedettoArrigoA,
pubmed-author:BonifacioDonatellaD,
pubmed-author:BrancaMargheritaM,
pubmed-author:CasolatiElena AEA,
pubmed-author:CiottiMarcoM,
pubmed-author:CostaSilvanoS,
pubmed-author:Di BonitoLuigiL,
pubmed-author:Di BonitoPaolaP,
pubmed-author:FavalliCartesioC,
pubmed-author:GiorgiColombaC,
pubmed-author:HPV-Pathogen ISS Study Group,
pubmed-author:MarianiLucianoL,
pubmed-author:PabaPierluigiP,
pubmed-author:SantiniDonatellaD,
pubmed-author:SyrjänenKariK,
pubmed-author:SyrjänenStinaS,
pubmed-author:ZanconatiFrancescaF
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pubmed:issnType |
Print
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113-21
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15923164-Carcinoma, Squamous Cell,
pubmed-meshheading:15923164-Cervical Intraepithelial Neoplasia,
pubmed-meshheading:15923164-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:15923164-Female,
pubmed-meshheading:15923164-Humans,
pubmed-meshheading:15923164-Immunohistochemistry,
pubmed-meshheading:15923164-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:15923164-Microtubule-Associated Proteins,
pubmed-meshheading:15923164-Neoplasm Proteins,
pubmed-meshheading:15923164-Papillomaviridae,
pubmed-meshheading:15923164-Papillomavirus Infections,
pubmed-meshheading:15923164-Polymerase Chain Reaction,
pubmed-meshheading:15923164-Prognosis,
pubmed-meshheading:15923164-Tumor Markers, Biological,
pubmed-meshheading:15923164-Uterine Cervical Neoplasms
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pubmed:year |
2005
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pubmed:articleTitle |
Survivin as a marker of cervical intraepithelial neoplasia and high-risk human papillomavirus and a predictor of virus clearance and prognosis in cervical cancer.
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pubmed:affiliation |
Unità Citoistopatologia, Centro Nazionale di, Epidemiologia, Sorveglianza e Promozione della Salute, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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