Source:http://linkedlifedata.com/resource/pubmed/id/15923045
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
2005-6-20
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pubmed:abstractText |
Naturally occurring CD4+CD25+ regulatory T cells (Treg) are essential for the control of unwanted autoimmune responses. In this study, we analysed their frequency in peripheral blood and in the thymus/thymomas of patients with myasthenia gravis (MG). We found a marked decrease in the number of CD4+CD25+ thymocytes in MG-associated thymomas, but no differences in the peripheral compartment, suggesting that the thymic development of Treg might be impaired in these patients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0165-5728
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
124-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15923045-Adult,
pubmed-meshheading:15923045-Age of Onset,
pubmed-meshheading:15923045-Aged,
pubmed-meshheading:15923045-Aged, 80 and over,
pubmed-meshheading:15923045-Antigens, CD,
pubmed-meshheading:15923045-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15923045-Female,
pubmed-meshheading:15923045-Flow Cytometry,
pubmed-meshheading:15923045-Humans,
pubmed-meshheading:15923045-Immunohistochemistry,
pubmed-meshheading:15923045-Male,
pubmed-meshheading:15923045-Middle Aged,
pubmed-meshheading:15923045-Myasthenia Gravis,
pubmed-meshheading:15923045-Thymoma,
pubmed-meshheading:15923045-Thymus Neoplasms
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pubmed:year |
2005
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pubmed:articleTitle |
Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma.
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pubmed:affiliation |
Department of General Neurology, Hertie Institute for Clinical Brain Research, Tuebingen University Hospital, Otfried-Müller-Strasse 27, D-72076 Tuebingen, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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