15922143

Source:http://linkedlifedata.com/resource/pubmed/id/15922143

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017398, umls-concept:C0024141
pubmed:issue	2
pubmed:dateCreated	2005-5-30
pubmed:abstractText	There are two primary mechanisms for studying the genetic forces at work in systemic lupus erythematosus (SLE). Several groups have collected large numbers of pedigrees in which multiple family members have SLE for use in linkage studies. These linkage studies serve to isolate areas of the genome in which susceptibility genes lie. Other groups have taken a more direct approach of investigating genes that might contribute to disease pathogenesis in sets of lupus subjects and matched controls. These association studies are accumulating in greater numbers as the technology to determine the genotype at a given locus becomes more accessible. This article discusses the results of both types of studies.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/AI053747, http://linkedlifedata.com/resource/pubmed/grant/AI24717, http://linkedlifedata.com/resource/pubmed/grant/AI31584, http://linkedlifedata.com/resource/pubmed/grant/AI54117, http://linkedlifedata.com/resource/pubmed/grant/AR048928, http://linkedlifedata.com/resource/pubmed/grant/AR049084, http://linkedlifedata.com/resource/pubmed/grant/AR12253, http://linkedlifedata.com/resource/pubmed/grant/AR42460, http://linkedlifedata.com/resource/pubmed/grant/AR48940, http://linkedlifedata.com/resource/pubmed/grant/AR49272, http://linkedlifedata.com/resource/pubmed/grant/DE15223, http://linkedlifedata.com/resource/pubmed/grant/RR020143, http://linkedlifedata.com/resource/pubmed/grant/RR025577, http://linkedlifedata.com/resource/pubmed/grant/RR14467
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8708093
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0889-857X
pubmed:author	pubmed-author:HarleyJohn BJB, pubmed-author:NathSwapan KSK, pubmed-author:SestakAndrea LAL
pubmed:issnType	Print
pubmed:volume	31
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	223-44, v
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:15922143-Genetic Linkage, pubmed-meshheading:15922143-Humans, pubmed-meshheading:15922143-Lupus Erythematosus, Systemic
pubmed:year	2005
pubmed:articleTitle	Genetics of systemic lupus erythematosus: how far have we come?
pubmed:affiliation	Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73003, USA. sestaka@omrf.ouhsc.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural