| pubmed-article:15919934 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15919934 | lifeskim:mentions | umls-concept:C0035736 | lld:lifeskim |
| pubmed-article:15919934 | lifeskim:mentions | umls-concept:C0032098 | lld:lifeskim |
| pubmed-article:15919934 | lifeskim:mentions | umls-concept:C1099354 | lld:lifeskim |
| pubmed-article:15919934 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:15919934 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15919934 | pubmed:dateCreated | 2005-5-27 | lld:pubmed |
| pubmed-article:15919934 | pubmed:abstractText | RNA silencing is conserved in a broad range of eukaryotes and includes the phenomena of RNA interference in animals and posttranscriptional gene silencing (PTGS) in plants. In plants, PTGS acts as an antiviral system; a successful virus infection requires suppression or evasion of the induced silencing response. Small interfering RNAs (siRNAs) accumulate in plants infected with positive-strand RNA viruses and provide specificity to this RNA-mediated defense. We present here the results of a survey of virus-specific siRNAs characterized by a sequence analysis of siRNAs from plants infected with Cymbidium ringspot tombusvirus (CymRSV). CymRSV siRNA sequences have a nonrandom distribution along the length of the viral genome, suggesting that there are hot spots for virus-derived siRNA generation. CymRSV siRNAs bound to the CymRSV p19 suppressor protein have the same asymmetry in strand polarity as the sequenced siRNAs and are imperfect double-stranded RNA duplexes. Moreover, an analysis of siRNAs derived from two other nonrelated positive-strand RNA viruses showed that they displayed the same asymmetry as CymRSV siRNAs. Finally, we show that Tobacco mosaic virus (TMV) carrying a short inverted repeat of the phytoene desaturase (PDS) gene triggered more accumulation of PDS siRNAs than the corresponding antisense PDS sequence. Taken together, these results suggest that virus-derived siRNAs originate predominantly by direct DICER cleavage of imperfect duplexes in the most folded regions of the positive strand of the viral RNA. | lld:pubmed |
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| pubmed-article:15919934 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15919934 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15919934 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15919934 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15919934 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15919934 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15919934 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:15919934 | pubmed:author | pubmed-author:MolnárAttilaA | lld:pubmed |
| pubmed-article:15919934 | pubmed:author | pubmed-author:BurgyánJózsef... | lld:pubmed |
| pubmed-article:15919934 | pubmed:author | pubmed-author:LakatosLóránt... | lld:pubmed |
| pubmed-article:15919934 | pubmed:author | pubmed-author:LacommeChrist... | lld:pubmed |
| pubmed-article:15919934 | pubmed:author | pubmed-author:CsorbaTiborT | lld:pubmed |
| pubmed-article:15919934 | pubmed:author | pubmed-author:VárallyayEvaE | lld:pubmed |
| pubmed-article:15919934 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15919934 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:15919934 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15919934 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15919934 | pubmed:pagination | 7812-8 | lld:pubmed |
| pubmed-article:15919934 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15919934 | pubmed:meshHeading | pubmed-meshheading:15919934... | lld:pubmed |
| pubmed-article:15919934 | pubmed:meshHeading | pubmed-meshheading:15919934... | lld:pubmed |
| pubmed-article:15919934 | pubmed:meshHeading | pubmed-meshheading:15919934... | lld:pubmed |
| pubmed-article:15919934 | pubmed:meshHeading | pubmed-meshheading:15919934... | lld:pubmed |
| pubmed-article:15919934 | pubmed:meshHeading | pubmed-meshheading:15919934... | lld:pubmed |
| pubmed-article:15919934 | pubmed:meshHeading | pubmed-meshheading:15919934... | lld:pubmed |
| pubmed-article:15919934 | pubmed:meshHeading | pubmed-meshheading:15919934... | lld:pubmed |
| pubmed-article:15919934 | pubmed:meshHeading | pubmed-meshheading:15919934... | lld:pubmed |
| pubmed-article:15919934 | pubmed:meshHeading | pubmed-meshheading:15919934... | lld:pubmed |
| pubmed-article:15919934 | pubmed:meshHeading | pubmed-meshheading:15919934... | lld:pubmed |
| pubmed-article:15919934 | pubmed:meshHeading | pubmed-meshheading:15919934... | lld:pubmed |
| pubmed-article:15919934 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15919934 | pubmed:articleTitle | Plant virus-derived small interfering RNAs originate predominantly from highly structured single-stranded viral RNAs. | lld:pubmed |
| pubmed-article:15919934 | pubmed:affiliation | Agricultural Biotechnology Center, Plant Biology Institute, P. O. Box 411, H-2101 Gödöllö, Hungary. | lld:pubmed |
| pubmed-article:15919934 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15919934 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
