Linked Life Data

1591945

Source:http://linkedlifedata.com/resource/pubmed/id/1591945

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-6-30
pubmed:abstractText
Antiproliferative effects of combined treatment with methylglyoxal bis(cyclopentylamidinohydrazone) (MGBCP), a polyamine biosynthesis inhibitor, and cepharanthine, a biscoclaurine alkaloid, on methicillin- and gentamicin-resistant Staphylococcus aureus were investigated. The bactericidal effect of MGBCP on S. aureus was potentiated by the cepharanthine treatment. Cellular polyamine levels of the bacteria treated with both MGBCP and cepharanthine were much lower than those of the bacteria treated with MGBCP alone. On the contrary, the cellular MGBCP concentration was much higher in the cepharanthine-treated bacteria. Thus, cepharanthine was considered to enhance the incorporation of MGBCP into the bacteria. The combination of MGBCP and cepharanthine resulted in greater suppression of macromolecular synthesis in the bacteria that might have caused greater suppression of bacterial growth.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0009-3157
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
107-11
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
An alkaloid, cepharanthine, potentiates the bactericidal effect of methylglyoxal bis (cyclopentylamidinohydrazone) on Staphylococcus aureus.
pubmed:affiliation
College of Medical Sciences, Mie University, Japan.
pubmed:publicationType
Journal Article