Linked Life Data

15918589

Source:http://linkedlifedata.com/resource/pubmed/id/15918589

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-5-27
pubmed:abstractText
The purpose of this study was to assess the direct effects of dobutamine on porcine coronary arteries and to investigate the mechanism of its action. Rings of coronary arteries from pigs were suspended in baths containing Krebs solution, and isometric tension was measured. The response to dobutamine (10(-8)-10(-3) M) was investigated in porcine coronary arterial rings contracted by KCl. The roles of endothelium, nitric oxide (NO), cyclic GMP (cGMP), prostaglandins and the adrenergic beta1, beta2-receptor on dobutamine-induced relaxation were also studied. Dobutamine inhibited the vasocontractivity to KCl and CaCl2, and relaxed porcine coronary artery. The relaxing response to dobutamine in coronary artery was significantly reduced by blockage of the adrenergic beta1-receptor, but not by removal of endothelium, blockage of the adrenergic beta2-receptor, inhibitors of nitric oxide synthase, guanylate cyclase and prostaglandin synthase. Our results suggest that dobutamine induces relaxation of isolated porcine coronary arteries via the adrenergic P1-receptor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0031-7144
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
375-7
pubmed:dateRevised
2007-1-29
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
The relaxant effect of dobutamine on porcine coronary arterial ring segments.
pubmed:affiliation
Department of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, PR China.
pubmed:publicationType
Journal Article, In Vitro