Linked Life Data

15917462

Source:http://linkedlifedata.com/resource/pubmed/id/15917462

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
2005-5-26
pubmed:abstractText
Thalamic projections to prefrontal cortex are important for executive aspects of attention. Using two-photon imaging in prefrontal brain slices, we show that nicotine and the wakefulness neuropeptide hypocretin (orexin) excite the same identified synapses of the thalamocortical arousal pathway within the prefrontal cortex. Although it is known that attention can be improved when nicotine is infused directly into the midlayer of the prefrontal cortex in the rat, the effects of hypocretin on attention are not known. The overlap in thalamocortical synapses excited by hypocretin and nicotine and the lack of direct postsynaptic effects prompted us to compare their effects on a sustained and divided attention task in the rat. Similar to nicotine, infusions of hypocretin-2 peptide into the prefrontal cortex significantly improved accuracy under high attentional demand without effects on other performance measures. We show for the first time that hypocretin can improve attentional processes relevant to executive functions of the prefrontal cortex.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
25
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5225-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:15917462-Action Potentials, pubmed-meshheading:15917462-Afferent Pathways, pubmed-meshheading:15917462-Animals, pubmed-meshheading:15917462-Animals, Newborn, pubmed-meshheading:15917462-Attention, pubmed-meshheading:15917462-Behavior, Animal, pubmed-meshheading:15917462-Calcium, pubmed-meshheading:15917462-Diagnostic Imaging, pubmed-meshheading:15917462-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:15917462-Neurons, pubmed-meshheading:15917462-Neuropeptides, pubmed-meshheading:15917462-Nicotine, pubmed-meshheading:15917462-Nicotinic Agonists, pubmed-meshheading:15917462-Photons, pubmed-meshheading:15917462-Prefrontal Cortex, pubmed-meshheading:15917462-Rats, pubmed-meshheading:15917462-Rats, Sprague-Dawley, pubmed-meshheading:15917462-Synapses, pubmed-meshheading:15917462-Thalamus
pubmed:year
2005
pubmed:articleTitle
Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat.
pubmed:affiliation
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA. evelyn.lambe@yale.edu
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural