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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2005-5-26
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pubmed:abstractText |
Linkage studies suggest the presence of putative risk and/or age-at-onset genes for Alzheimer's disease on Chromosome 10. Recently, a genomic converging approach using a combination of linkage, expression and association studies has reported significant associations of the glutathione S-transferase omega 1 and 2 (GSTO1 and GSTO2) genes and possibly the protease serine 11 (PRSS11) gene on chromosome 10 with age-at-onset, but not risk, for Alzheimer's disease (AD) and Parkinson disease. We investigated the association of the reported three polymorphisms in 990 sporadic late-onset AD cases (26% autopsy confirmed) and 735 controls. In our sample, we found no association either with age-at-onset in AD cases or with disease risk in the case-control cohort. However, haplotype analysis revealed a modest association of one haplotype with AD risk (p = 0.04). Additional markers in these genes need to be screened to explore their role in the etiology of AD.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0197-4580
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1161-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15917099-Adult,
pubmed-meshheading:15917099-Age of Onset,
pubmed-meshheading:15917099-Aged,
pubmed-meshheading:15917099-Alzheimer Disease,
pubmed-meshheading:15917099-Case-Control Studies,
pubmed-meshheading:15917099-Chromosomes, Human, Pair 10,
pubmed-meshheading:15917099-Cohort Studies,
pubmed-meshheading:15917099-DNA Mutational Analysis,
pubmed-meshheading:15917099-Female,
pubmed-meshheading:15917099-Genetic Markers,
pubmed-meshheading:15917099-Genetic Predisposition to Disease,
pubmed-meshheading:15917099-Genetic Testing,
pubmed-meshheading:15917099-Genotype,
pubmed-meshheading:15917099-Glutathione Transferase,
pubmed-meshheading:15917099-Haplotypes,
pubmed-meshheading:15917099-Humans,
pubmed-meshheading:15917099-Male,
pubmed-meshheading:15917099-Middle Aged,
pubmed-meshheading:15917099-Polymorphism, Single Nucleotide,
pubmed-meshheading:15917099-Serine Endopeptidases
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pubmed:articleTitle |
Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease.
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pubmed:affiliation |
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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