Source:http://linkedlifedata.com/resource/pubmed/id/15917098
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2005-5-26
|
| pubmed:abstractText |
Despite biological support for a role of angiotensin converting enzyme (ACE) in Alzheimer's disease (AD), studies assessing the ACE I/D polymorphism in AD are conflicting. We re-evaluated this association in the Rotterdam Study, a population-based cohort study. The mechanism of association was further explored by adjusting for vascular factors, and by analysing atrophy, white matter lesions and infarcts on MRI in non-demented individuals. Genotypes were available for 6488 participants. During average follow-up of 6 years 250 subjects developed AD. MRI data were available for 494 non-demented participants. Homozygosity for the I-allele conferred a slightly increased risk of AD compared to carrying a D-allele (RR 1.12 (95% CI 0.99-1.25)). This increase was only significant in women, and independent of vascular factors (RR 1.39 (95% CI 1.14-1.69)). Non-demented women with the II genotype had smaller hippocampal and amygdalar volumes. Vascular pathology was not significantly associated with ACE. This suggests a modest but significant increase in risk of AD and early AD pathology in women homozygous for the ACE I-allele independent of vascular factors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0197-4580
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1153-9
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:15917098-Aged,
pubmed-meshheading:15917098-Alzheimer Disease,
pubmed-meshheading:15917098-Amygdala,
pubmed-meshheading:15917098-Atrophy,
pubmed-meshheading:15917098-Cerebrovascular Disorders,
pubmed-meshheading:15917098-Cohort Studies,
pubmed-meshheading:15917098-DNA Mutational Analysis,
pubmed-meshheading:15917098-Female,
pubmed-meshheading:15917098-Genetic Predisposition to Disease,
pubmed-meshheading:15917098-Genetic Testing,
pubmed-meshheading:15917098-Genotype,
pubmed-meshheading:15917098-Hippocampus,
pubmed-meshheading:15917098-Homozygote,
pubmed-meshheading:15917098-Humans,
pubmed-meshheading:15917098-Magnetic Resonance Imaging,
pubmed-meshheading:15917098-Male,
pubmed-meshheading:15917098-Middle Aged,
pubmed-meshheading:15917098-Nerve Fibers, Myelinated,
pubmed-meshheading:15917098-Netherlands,
pubmed-meshheading:15917098-Peptidyl-Dipeptidase A,
pubmed-meshheading:15917098-Polymorphism, Genetic,
pubmed-meshheading:15917098-Sex Factors
|
| pubmed:articleTitle |
ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala.
|
| pubmed:affiliation |
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|